Pre-clinical and clinical evaluation of the malaria vaccines RH5-VLP and PfSPZ vaccine

Pre-clinical and clinical evaluation of the malaria vaccines RH5-VLP and PfSPZ vaccine

<p>Despite progress through expanded use of bed nets and anti-malarial drugs, <em>Plasmodium falciparum</em> (Pf) malaria caused about 200 million cases and 500,000 deaths in 2015. An ideal vaccine would reduce the burden of disease and interrupt transmission. Despite decades of ef...

Bibliografski detalji
Glavni autor:	Ishizuka, A
Daljnji autori:	Draper, S
Format:	Disertacija
Izdano:	2016

Slični predmeti

Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity
od: Bhatia, Sangeeta
Izdano: (2022)

Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial
od: Zita Sulyok, i dr.
Izdano: (2021-05-01)

A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection
od: Benjamin Mordmüller, i dr.
Izdano: (2022-08-01)

PfSPZ-CVac malaria vaccine demonstrates safety among malaria-experienced adults: A randomized, controlled phase 1 trial
od: Drissa Coulibaly, i dr.
Izdano: (2022-10-01)

PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adultsResearch in context
od: Anneth Tumbo, i dr.
Izdano: (2024-10-01)

Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa
od: Joana C. Silva, i dr.
Izdano: (2022-06-01)

Adaptive clinical trials of three PfSPZ products for development of a whole sporozoite vaccine that prevents <it>Plasmodium falciparum</it> infection, disease and transmission
od: Hoffman Stephen L
Izdano: (2012-10-01)

Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
od: Natasha KC, i dr.
Izdano: (2022-10-01)

Caregiver and community perceptions and experiences participating in an infant malaria prevention trial of PfSPZ Vaccine administered by direct venous inoculation: a qualitative study in Siaya County, western Kenya
od: Florence Achieng, i dr.
Izdano: (2020-06-01)

PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection.
od: Sean C Murphy, i dr.
Izdano: (2021-05-01)

Insights into the design of an improved PfRH5 malaria immunogen using vaccine-induced monoclonal antibodies
od: Alanine, DGW
Izdano: (2017)

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.
od: Douglas, A, i dr.
Izdano: (2011)

Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5
od: Khadidiatou Mangou, i dr.
Izdano: (2022-11-01)

Investigation of the Plasmodium falciparum RH5-Interacting Protein (PfRIPR) as a blood-stage malaria vaccine target
od: Williams, BG
Izdano: (2021)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
od: Thiam, LG, i dr.
Izdano: (2024)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
od: Laty G. Thiam, i dr.
Izdano: (2024-10-01)

DOPS Adjuvant Confers Enhanced Protection against Malaria for VLP-TRAP Based Vaccines
od: Gustavo Cabral-Miranda, i dr.
Izdano: (2018-11-01)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
od: Harrison, TE, i dr.
Izdano: (2024)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
od: Thomas E Harrison, i dr.
Izdano: (2024-09-01)

DOPS adjuvant confers enhanced protection against malaria for VLP-TRAP based vaccines
od: Cabral-Miranda, G, i dr.
Izdano: (2018)

The Immunogenicity of a VLP-based Malaria Vaccine Targeting CSP in Pregnant and Neonatal Mice
od: Lucie Jelínková, i dr.
Izdano: (2023-01-01)

Establishment of an Antiplasmodial Vaccine Based on PfRH5-Encoding RNA Replicons Stabilized by Cationic Liposomes
od: Wesley L. Fotoran, i dr.
Izdano: (2023-04-01)

RNA Phage VLP-Based Vaccine Platforms
od: David S. Peabody, i dr.
Izdano: (2021-08-01)

Pre-clinical and clinical development of the first placental malaria vaccine
od: Caroline Pehrson, i dr.
Izdano: (2017-06-01)

Immunodrugs: therapeutic VLP-based vaccines for chronic diseases.
od: Jennings, G, i dr.
Izdano: (2009)

Zika virus-like particle (VLP) based vaccine.
od: Hélène Boigard, i dr.
Izdano: (2017-05-01)

Optimization of bearing structure of ballast leveling machine SPZ-5/UA
od: S. A. Kostritsya, i dr.
Izdano: (2013-04-01)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
od: Frederica D Partey, i dr.
Izdano: (2018-01-01)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria
od: Partey, F, i dr.
Izdano: (2018)

The RH5-CyRPA-Ripr complex as a malaria vaccine target
od: Ragotte, RJ, i dr.
Izdano: (2020)

Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine
od: Minna M. Hankaniemi, i dr.
Izdano: (2020-08-01)

Significance of VLPs in Vlp-circRNA vaccines: a vaccine candidate or delivery vehicle?
od: Reeshu Gupta, i dr.
Izdano: (2024-12-01)

A DNA Vaccine Encoding <i>Plasmodium falciparum</i> PfRH5 in Cationic Liposomes for Dermal Tattooing Immunization
od: Wesley Luzetti Fotoran, i dr.
Izdano: (2020-10-01)

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
od: Frederica D Partey, i dr.
Izdano: (2018-01-01)

Targeting PfRh5 on Merozoites to Prevent Basigin Binding
od: Papadopoulos Konstantinos
Izdano: (2012-10-01)

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.
od: Douglas, A, i dr.
Izdano: (2015)

Asexual Blood-Stage Malaria Vaccine Candidate PfRipr5: Enhanced Production in Insect Cells
od: Ricardo Correia, i dr.
Izdano: (2022-06-01)

VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases
od: Aline Maria Vasconcelos Queiroz, i dr.
Izdano: (2021-03-01)

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.
od: Douglas, A, i dr.
Izdano: (2014)

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
od: Bustamante, L, i dr.
Izdano: (2013)