Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from...
| Auteur principal: | |
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| Format: | Journal article |
| Langue: | English |
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2011
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| _version_ | 1826272434651660288 |
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| author | McCarthy, M |
| author_facet | McCarthy, M |
| author_sort | McCarthy, M |
| collection | OXFORD |
| description | Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research. |
| first_indexed | 2024-03-06T22:12:31Z |
| format | Journal article |
| id | oxford-uuid:524dfe67-c9db-4241-a74b-b6a168384be2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:12:31Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:524dfe67-c9db-4241-a74b-b6a168384be22022-03-26T16:24:48ZDorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:524dfe67-c9db-4241-a74b-b6a168384be2EnglishSymplectic Elements at Oxford2011McCarthy, MRecent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research. |
| spellingShingle | McCarthy, M Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes. |
| title | Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes. |
| title_full | Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes. |
| title_fullStr | Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes. |
| title_full_unstemmed | Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes. |
| title_short | Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes. |
| title_sort | dorothy hodgkin lecture 2010 from hype to hope a journey through the genetics of type 2 diabetes |
| work_keys_str_mv | AT mccarthym dorothyhodgkinlecture2010fromhypetohopeajourneythroughthegeneticsoftype2diabetes |