Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.

Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from...

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Huvudupphovsman: McCarthy, M
Materialtyp: Journal article
Språk:English
Publicerad: 2011
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author McCarthy, M
author_facet McCarthy, M
author_sort McCarthy, M
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description Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research.
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spelling oxford-uuid:524dfe67-c9db-4241-a74b-b6a168384be22022-03-26T16:24:48ZDorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:524dfe67-c9db-4241-a74b-b6a168384be2EnglishSymplectic Elements at Oxford2011McCarthy, MRecent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research.
spellingShingle McCarthy, M
Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
title Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
title_full Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
title_fullStr Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
title_full_unstemmed Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
title_short Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
title_sort dorothy hodgkin lecture 2010 from hype to hope a journey through the genetics of type 2 diabetes
work_keys_str_mv AT mccarthym dorothyhodgkinlecture2010fromhypetohopeajourneythroughthegeneticsoftype2diabetes