Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.

Interferon (IFN)-gamma was originally characterized as a pro-inflammatory cytokine with T helper type 1-inducing activity, but subsequent work has demonstrated that mice deficient in IFN-gamma or IFN-gamma receptor show exacerbated inflammatory responses and accelerated allograft rejection, suggesti...

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書目詳細資料
Main Authors: Feng, G, Gao, W, Strom, T, Oukka, M, Francis, R, Wood, K, Bushell, A
格式: Journal article
語言:English
出版: 2008