Ring closing metathesis for the asymmetric synthesis of (S)-homopipecolic acid, (S)-homoproline and (S)-coniine

Diastereoselective conjugate addition of lithium (S)-N-allyl-N-α-methylbenzylamide to α,β-unsaturated esters or Weinreb amides, followed by ring closing metathesis is used to afford the cyclic β-amino acids (S)-homopipecolic acid and (S)-homoproline and the amine (S)-coniine in high ee.

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Davies, S, Iwamoto, K, Smethurst, C, Smith, A, Rodriguez-Solla, H
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2002