Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors.
It has been established that 5-HT(1A) receptors are expressed both presynaptically as autoreceptors by 5-HT containing neurones, and postsynaptically by a variety of other neurones. Activation of either somatodendritic 5-HT(1A) autoreceptors or postsynaptic 5-HT(1A) receptors induces hyperpolarisati...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797068679313096704 |
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| author | Hajós, M Hoffmann, W Tetko, I Hyland, B Sharp, T Villa, A |
| author_facet | Hajós, M Hoffmann, W Tetko, I Hyland, B Sharp, T Villa, A |
| author_sort | Hajós, M |
| collection | OXFORD |
| description | It has been established that 5-HT(1A) receptors are expressed both presynaptically as autoreceptors by 5-HT containing neurones, and postsynaptically by a variety of other neurones. Activation of either somatodendritic 5-HT(1A) autoreceptors or postsynaptic 5-HT(1A) receptors induces hyperpolarisation and inhibition of action potential discharge of the neurones, but it is unclear whether 5-HT(1A) receptors are under a general tonic influence by 5-HT. In the present study, using single unit recordings from both anesthetized and non-anesthetized rats, we show that the activity of neurones in the medial prefrontal cortex is not altered by systemic administration of the selective 5-HT(1A) receptor antagonist, WAY 100635. In contrast, WAY 100635 increased the firing rate of 5-HT neurones in the dorsal raphe nucleus. Our findings indicate a tonic activation of presynaptic somatodendritic but not postsynaptic cortical 5-HT(1A) receptors. |
| first_indexed | 2024-03-06T22:13:38Z |
| format | Journal article |
| id | oxford-uuid:52a98996-0e1d-473d-ae1f-eeae356234ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:13:38Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:52a98996-0e1d-473d-ae1f-eeae356234ad2022-03-26T16:26:50ZDifferent tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:52a98996-0e1d-473d-ae1f-eeae356234adEnglishSymplectic Elements at Oxford2001Hajós, MHoffmann, WTetko, IHyland, BSharp, TVilla, AIt has been established that 5-HT(1A) receptors are expressed both presynaptically as autoreceptors by 5-HT containing neurones, and postsynaptically by a variety of other neurones. Activation of either somatodendritic 5-HT(1A) autoreceptors or postsynaptic 5-HT(1A) receptors induces hyperpolarisation and inhibition of action potential discharge of the neurones, but it is unclear whether 5-HT(1A) receptors are under a general tonic influence by 5-HT. In the present study, using single unit recordings from both anesthetized and non-anesthetized rats, we show that the activity of neurones in the medial prefrontal cortex is not altered by systemic administration of the selective 5-HT(1A) receptor antagonist, WAY 100635. In contrast, WAY 100635 increased the firing rate of 5-HT neurones in the dorsal raphe nucleus. Our findings indicate a tonic activation of presynaptic somatodendritic but not postsynaptic cortical 5-HT(1A) receptors. |
| spellingShingle | Hajós, M Hoffmann, W Tetko, I Hyland, B Sharp, T Villa, A Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. |
| title | Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. |
| title_full | Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. |
| title_fullStr | Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. |
| title_full_unstemmed | Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. |
| title_short | Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. |
| title_sort | different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5 ht 1a receptors |
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