Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.

Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.

Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The BRCA1 protein plays a central role in DNA repair, a mechanism that is particular...

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Bibliographic Details
Main Authors: Cox, D, Simard, J, Sinnett, D, Hamdi, Y, Soucy, P, Ouimet, M, Barjhoux, L, Verny-Pierre, C, McGuffog, L, Healey, S, Szabo, C, Greene, M, Mai, P, Andrulis, I, Thomassen, M, Gerdes, A, Caligo, M, Friedman, E, Laitman, Y, Kaufman, B, Paluch, S, Borg, Å, Karlsson, P, Askmalm, MS, Bustinza, G
Format: Journal article
Language:English
Published: 2011

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