Coexistence of schizophrenia and epilepsy: record-linkage studies.
For many years, there has been interest in a possible link between epilepsy and schizophrenia. A recent study found a strong, bidirectional link between the two conditions: people with one had a higher than average risk of having the other. Using two large data sets of hospital admission data, we in...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797068690186829824 |
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| author | Wotton, C Goldacre, M |
| author_facet | Wotton, C Goldacre, M |
| author_sort | Wotton, C |
| collection | OXFORD |
| description | For many years, there has been interest in a possible link between epilepsy and schizophrenia. A recent study found a strong, bidirectional link between the two conditions: people with one had a higher than average risk of having the other. Using two large data sets of hospital admission data, we investigated whether schizophrenia and epilepsy occur together in individuals more commonly than expected by chance. We undertook a retrospective cohort study using the Oxford Record Linkage Study (ORLS) and English national linked Hospital Episode Statistics to investigate the coexistence of these conditions. There was an elevated risk of epilepsy in people admitted to hospital with schizophrenia (ORLS rate ratio 2.1, 95% confidence interval 1.6-2.6; England 3.0, 2.9-3.1) and an elevated risk of schizophrenia in people admitted to hospital with epilepsy (ORLS 5.1, 4.1-6.2; England 4.5, 4.3-4.6). We found no consistent difference between male and female patients. Schizophrenia and epilepsy occur together in individuals more frequently than expected by chance. |
| first_indexed | 2024-03-06T22:13:48Z |
| format | Journal article |
| id | oxford-uuid:52b9f9c2-e74c-49b6-b702-f17e877a5207 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:13:48Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:52b9f9c2-e74c-49b6-b702-f17e877a52072022-03-26T16:27:08ZCoexistence of schizophrenia and epilepsy: record-linkage studies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:52b9f9c2-e74c-49b6-b702-f17e877a5207EnglishSymplectic Elements at Oxford2012Wotton, CGoldacre, MFor many years, there has been interest in a possible link between epilepsy and schizophrenia. A recent study found a strong, bidirectional link between the two conditions: people with one had a higher than average risk of having the other. Using two large data sets of hospital admission data, we investigated whether schizophrenia and epilepsy occur together in individuals more commonly than expected by chance. We undertook a retrospective cohort study using the Oxford Record Linkage Study (ORLS) and English national linked Hospital Episode Statistics to investigate the coexistence of these conditions. There was an elevated risk of epilepsy in people admitted to hospital with schizophrenia (ORLS rate ratio 2.1, 95% confidence interval 1.6-2.6; England 3.0, 2.9-3.1) and an elevated risk of schizophrenia in people admitted to hospital with epilepsy (ORLS 5.1, 4.1-6.2; England 4.5, 4.3-4.6). We found no consistent difference between male and female patients. Schizophrenia and epilepsy occur together in individuals more frequently than expected by chance. |
| spellingShingle | Wotton, C Goldacre, M Coexistence of schizophrenia and epilepsy: record-linkage studies. |
| title | Coexistence of schizophrenia and epilepsy: record-linkage studies. |
| title_full | Coexistence of schizophrenia and epilepsy: record-linkage studies. |
| title_fullStr | Coexistence of schizophrenia and epilepsy: record-linkage studies. |
| title_full_unstemmed | Coexistence of schizophrenia and epilepsy: record-linkage studies. |
| title_short | Coexistence of schizophrenia and epilepsy: record-linkage studies. |
| title_sort | coexistence of schizophrenia and epilepsy record linkage studies |
| work_keys_str_mv | AT wottonc coexistenceofschizophreniaandepilepsyrecordlinkagestudies AT goldacrem coexistenceofschizophreniaandepilepsyrecordlinkagestudies |