The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

iRhom proteins are catalytically inactive relatives of rhomboid intramembrane proteases. There is a rapidly growing body of evidence that these pseudoenzymes have a central function in regulating inflammatory and growth factor signalling and consequent roles in many diseases. iRhom pseudoproteases h...

Bibliografiset tiedot
Päätekijät:	Dulloo, I, Muliyil, S, Freeman, M
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	Royal Society 2019

Samankaltaisia teoksia

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases
Tekijä: Iqbal Dulloo, et al.
Julkaistu: (2019-03-01)

Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells
Tekijä: Anja Adelina Giese, et al.
Julkaistu: (2021-12-01)

Regulation of cell signalling by iRhoms
Tekijä: Sieber, B
Julkaistu: (2019)

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
Tekijä: Ioanna Oikonomidi, et al.
Julkaistu: (2018-06-01)

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.
Tekijä: Adrain, C, et al.
Julkaistu: (2012)

The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders
Tekijä: Ramasatyaveni Geesala, et al.
Julkaistu: (2020-11-01)

Molecular mechanisms of ADAM17 regulation by iRhom2 in cell signalling
Tekijä: Lu, F
Julkaistu: (2022)

iRhom2 is required for the secretion of mouse TNFα.
Tekijä: Siggs, O, et al.
Julkaistu: (2012)

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation
Tekijä: Christova, Y, et al.
Julkaistu: (2013)

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.
Tekijä: Christova, Y, et al.
Julkaistu: (2013)

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
Tekijä: Siggs, O, et al.
Julkaistu: (2014)

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
Tekijä: Owen M. Siggs, et al.
Julkaistu: (2014-11-01)

Towards a structural understanding of the iRhom/ADAM17 complex
Tekijä: Shah, A
Julkaistu: (2020)

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.
Tekijä: Adrain, C, et al.
Julkaistu: (2012)

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction
Tekijä: Barnette, D, et al.
Julkaistu: (2018)

Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal Cancer
Tekijä: Stephen Murtough, et al.
Julkaistu: (2024-01-01)

Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells
Tekijä: Aaron Babendreyer, et al.
Julkaistu: (2020-12-01)

Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
Tekijä: Zhangyi Luo, et al.
Julkaistu: (2024-01-01)

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution
Tekijä: Matteo Calligaris, et al.
Julkaistu: (2021-02-01)

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
Tekijä: Marina Badenes, et al.
Julkaistu: (2020-01-01)

FRMD8 is a novel regulator of iRhom-dependent ADAM17 activity
Tekijä: Künzel, U
Julkaistu: (2017)

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
Tekijä: Kuenzel, U, et al.
Julkaistu: (2018)

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
Tekijä: Grieve, A, et al.
Julkaistu: (2017)

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling
Tekijä: Adam Graham Grieve, et al.
Julkaistu: (2017-04-01)

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
Tekijä: Ulrike Künzel, et al.
Julkaistu: (2018-06-01)

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
Tekijä: Paola Arcidiacono, et al.
Julkaistu: (2018-03-01)

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
Tekijä: Miguel Cavadas, et al.
Julkaistu: (2017-10-01)

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA.
Tekijä: Wei-Wei Luo, et al.
Julkaistu: (2017-11-01)

The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner
Tekijä: Joseph Skurski, et al.
Julkaistu: (2021-01-01)

A mass spectrometry-based screen reveals FRMD8 as a novel regulator of iRhom/ADAM17-dependent inflammatory and growth factor signalling
Tekijä: Kuenzel, U, et al.
Julkaistu: (2017)

4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation
Tekijä: Cong Zhou, et al.
Julkaistu: (2020-12-01)

Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats
Tekijä: Su Liu, et al.
Julkaistu: (2018-01-01)

Targeting iRhom2/ADAM17 attenuates COVID-19-induced cytokine release from cultured lung epithelial cells
Tekijä: Vitoria Mattos Pereira, et al.
Julkaistu: (2024-09-01)

iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress
Tekijä: Ge Chenxu, et al.
Julkaistu: (2018-10-01)

Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking
Tekijä: Taylor J. Louis, et al.
Julkaistu: (2022-05-01)

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.
Tekijä: Zettl, M, et al.
Julkaistu: (2011)

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals.
Tekijä: Amy E Rohlfing, et al.
Julkaistu: (2019-07-01)

Stress-related expression of the chloroplast EGY3 pseudoprotease and its possible impact on chloroplasts’ proteome composition
Tekijä: Małgorzata Adamiec, et al.
Julkaistu: (2022-07-01)

Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates
Tekijä: Anahita Nejatfard, et al.
Julkaistu: (2022-03-01)

The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.
Tekijä: Christine R Collins, et al.
Julkaistu: (2017-07-01)