Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection.
A longitudinal study of the CD8+ TCR variable (Vbeta) chain repertoire was performed in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV) using both TCR Vbeta chain-specific monoclonal antibodies and TCR beta chain CDR3 length analysis. Expansions of subpopulations of...
| Main Authors: | , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
1998
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| _version_ | 1826272525962706944 |
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| author | Wilson, J Cranage, M Cook, N Leech, S Mcmichael, A Callan, M |
| author_facet | Wilson, J Cranage, M Cook, N Leech, S Mcmichael, A Callan, M |
| author_sort | Wilson, J |
| collection | OXFORD |
| description | A longitudinal study of the CD8+ TCR variable (Vbeta) chain repertoire was performed in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV) using both TCR Vbeta chain-specific monoclonal antibodies and TCR beta chain CDR3 length analysis. Expansions of subpopulations of CD8+ T cells were detected during the acute phase of SIV infection. In all monkeys studied, monoclonal expansions persisted for at least 18 months and increasingly dominated the repertoire of CD8+ T cells expressing the relevant Vbeta chain. This study shows that persistent CD8+ T cell expansions develop in response to a virus infection. This is important not only for our understanding of the T cell response to viruses but also for understanding the factors that determine the normal CD8+ TCR repertoire. |
| first_indexed | 2024-03-06T22:13:57Z |
| format | Journal article |
| id | oxford-uuid:52c70208-e2fe-4f67-9c3c-30e1e7063d22 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:13:57Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:52c70208-e2fe-4f67-9c3c-30e1e7063d222022-03-26T16:27:26ZEvidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:52c70208-e2fe-4f67-9c3c-30e1e7063d22EnglishSymplectic Elements at Oxford1998Wilson, JCranage, MCook, NLeech, SMcmichael, ACallan, MA longitudinal study of the CD8+ TCR variable (Vbeta) chain repertoire was performed in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV) using both TCR Vbeta chain-specific monoclonal antibodies and TCR beta chain CDR3 length analysis. Expansions of subpopulations of CD8+ T cells were detected during the acute phase of SIV infection. In all monkeys studied, monoclonal expansions persisted for at least 18 months and increasingly dominated the repertoire of CD8+ T cells expressing the relevant Vbeta chain. This study shows that persistent CD8+ T cell expansions develop in response to a virus infection. This is important not only for our understanding of the T cell response to viruses but also for understanding the factors that determine the normal CD8+ TCR repertoire. |
| spellingShingle | Wilson, J Cranage, M Cook, N Leech, S Mcmichael, A Callan, M Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection. |
| title | Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection. |
| title_full | Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection. |
| title_fullStr | Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection. |
| title_full_unstemmed | Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection. |
| title_short | Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection. |
| title_sort | evidence for the persistence of monoclonal expansions of cd8 t cells following primary simian immunodeficiency virus infection |
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