Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome.

Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome.

The Mendelian tumour syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and hereditary paragangliomatosis with phaeochromocytomas (HPGL) result from mutations in nuclear genes (FH and SDHB/C/D, respectively) that encode Krebs cycle enzymes. HPGL tumours are highly vascular and there i...

Celý popis

Podrobná bibliografie
Hlavní autoři: Pollard, P, Wortham, N, Barclay, E, Alam, A, Elia, G, Manek, S, Poulsom, R, Tomlinson, I
Médium: Journal article
Jazyk:English
Vydáno: 2005

Podobné jednotky

Podobné jednotky