Human Semaphorin 3 variants link melanocortin circuit development and energy balance

Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants in SEMA3A-G and their receptors (PLXNA1-4; NRP1-2) in 573 severely obes...

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Detalles Bibliográficos
Main Authors:	Van Der Klaauw, AA, Croizier, S, De Oliveira, E, Stadler, LKJ, Park, S, Kong, Y, Banton, MC, Tandon, P, Hendricks, AE, Keogh, JM, Riley, SE, Papadia, S, Henning, E, Bounds, R, Bochukova, EG, Mistry, V, O'Rahilly, S, Simerly, RB, Interval, Uk10K Consortium, Minchin, JEN, Barroso, I, Jones, EY, Bouret, SG, Farooqi, IS
Formato:	Journal article
Idioma:	English
Publicado:	Elsevier 2019

Human Semaphorin 3 variants link melanocortin circuit development and energy balance

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