Crystallization and functional analysis of a soluble deglycosylated form of the human costimulatory molecule B7-1.

Crystallization and functional analysis of a soluble deglycosylated form of the human costimulatory molecule B7-1.

The interactions of B7-1 with CD28 and CTLA-4 modulate the course of human immune responses, making B7-1 an important target for developing structure-based therapeutics. B7-1 is, however, one of the most heavily glycosylated proteins found at the leukocyte cell surface, complicating the structural a...

Полное описание

Библиографические подробности
Главные авторы:	Davis, S, Ikemizu, S, Collins, A, Fennelly, J, Harlos, K, Jones, E, Stuart, D
Формат:	Journal article
Язык:	English
Опубликовано:	2001

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