Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-assoc...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| مؤلفون آخرون: | |
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Springer Nature
2023
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| _version_ | 1826311929138774016 |
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| author | Michael, BD Dunai, C Needham, EJ Tharmaratnam, K Williams, R Huang, Y Boardman, SA Clark, JJ Sharma, P Subramaniam, K Wood, GK Collie, C Digby, R Ren, A Norton, E Leibowitz, M Ebrahimi, S Fower, A Fox, H Tato, E Ellul, MA Sunderland, G Held, M Hetherington, C Egbe, FN Palmos, A Stirrups, K Grundmann, A Chiollaz, A-C Sanchez, J-C Stewart, JP Griffiths, M Solomon, T Breen, G Coles, AJ Kingston, N Bradley, JR Chinnery, PF Cavanagh, J Irani, SR Vincent, A Baillie, JK Openshaw, PJ Semple, MG Taams, LS Menon, DK Horby, PW Klenerman, P Merson, L Sigfrid, L Stuart, D Lee, J Plotkin, D Carson, G Duff, E Miller, K Husain, M Harrison, PJ Jezzard, P Smith, S |
| author2 | ISARIC4C Investigators |
| author_facet | ISARIC4C Investigators Michael, BD Dunai, C Needham, EJ Tharmaratnam, K Williams, R Huang, Y Boardman, SA Clark, JJ Sharma, P Subramaniam, K Wood, GK Collie, C Digby, R Ren, A Norton, E Leibowitz, M Ebrahimi, S Fower, A Fox, H Tato, E Ellul, MA Sunderland, G Held, M Hetherington, C Egbe, FN Palmos, A Stirrups, K Grundmann, A Chiollaz, A-C Sanchez, J-C Stewart, JP Griffiths, M Solomon, T Breen, G Coles, AJ Kingston, N Bradley, JR Chinnery, PF Cavanagh, J Irani, SR Vincent, A Baillie, JK Openshaw, PJ Semple, MG Taams, LS Menon, DK Horby, PW Klenerman, P Merson, L Sigfrid, L Stuart, D Lee, J Plotkin, D Carson, G Duff, E Miller, K Husain, M Harrison, PJ Jezzard, P Smith, S |
| author_sort | Michael, BD |
| collection | OXFORD |
| description | To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely. |
| first_indexed | 2024-03-07T08:18:32Z |
| format | Journal article |
| id | oxford-uuid:52dc98d7-826c-4627-965f-019d4784b670 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:18:32Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:52dc98d7-826c-4627-965f-019d4784b6702024-01-16T11:48:48ZPara-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responsesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:52dc98d7-826c-4627-965f-019d4784b670EnglishSymplectic ElementsSpringer Nature2023Michael, BDDunai, CNeedham, EJTharmaratnam, KWilliams, RHuang, YBoardman, SAClark, JJSharma, PSubramaniam, KWood, GKCollie, CDigby, RRen, ANorton, ELeibowitz, MEbrahimi, SFower, AFox, HTato, EEllul, MASunderland, GHeld, MHetherington, CEgbe, FNPalmos, AStirrups, KGrundmann, AChiollaz, A-CSanchez, J-CStewart, JPGriffiths, MSolomon, TBreen, GColes, AJKingston, NBradley, JRChinnery, PFCavanagh, JIrani, SRVincent, ABaillie, JKOpenshaw, PJSemple, MGTaams, LSMenon, DKHorby, PWKlenerman, PMerson, LSigfrid, LStuart, DLee, JPlotkin, DCarson, GDuff, EMiller, KHusain, MHarrison, PJJezzard, PSmith, SISARIC4C InvestigatorsCOVID-CNS ConsortiumTo understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely. |
| spellingShingle | Michael, BD Dunai, C Needham, EJ Tharmaratnam, K Williams, R Huang, Y Boardman, SA Clark, JJ Sharma, P Subramaniam, K Wood, GK Collie, C Digby, R Ren, A Norton, E Leibowitz, M Ebrahimi, S Fower, A Fox, H Tato, E Ellul, MA Sunderland, G Held, M Hetherington, C Egbe, FN Palmos, A Stirrups, K Grundmann, A Chiollaz, A-C Sanchez, J-C Stewart, JP Griffiths, M Solomon, T Breen, G Coles, AJ Kingston, N Bradley, JR Chinnery, PF Cavanagh, J Irani, SR Vincent, A Baillie, JK Openshaw, PJ Semple, MG Taams, LS Menon, DK Horby, PW Klenerman, P Merson, L Sigfrid, L Stuart, D Lee, J Plotkin, D Carson, G Duff, E Miller, K Husain, M Harrison, PJ Jezzard, P Smith, S Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses |
| title | Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses |
| title_full | Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses |
| title_fullStr | Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses |
| title_full_unstemmed | Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses |
| title_short | Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses |
| title_sort | para infectious brain injury in covid 19 persists at follow up despite attenuated cytokine and autoantibody responses |
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