Molecular basis and regulation of OTULIN-LUBAC interaction

<p style="text-align:justify;"> The linear ubiquitin (Ub) chain assembly complex (LUBAC) generates Met1-linked “linear” Ub chains that regulate the activation of the nuclear factor κB (NFκB) transcription factor and other processes. We recently discovered OTULIN as a deubiquitinase...

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Main Authors: Elliott, PR, Nielsen, SV, Marco-Casanova, P, Fiil, BK, Keusekotten, K, Mailand, N, Freund, SMV, Gyrd-Hansen, M, Komander, D
格式: Journal article
语言:English
出版: Elsevier 2014