Mdm2 widens its repertoire.
The p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects diverse cellular processes which include transcription, DNA synthesis and repair, cell cycle arrest, senescence and apoptosis. The Mdm2 oncoprotein is a primary regulator of p53, mediating p53 control via u...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826272561936203776 |
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| author | Coutts, A La Thangue, N |
| author_facet | Coutts, A La Thangue, N |
| author_sort | Coutts, A |
| collection | OXFORD |
| description | The p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects diverse cellular processes which include transcription, DNA synthesis and repair, cell cycle arrest, senescence and apoptosis. The Mdm2 oncoprotein is a primary regulator of p53, mediating p53 control via ubiquitin-dependent proteasomal degradation. During DNA damage, the interaction between p53 and Mdm2 is reduced, which allows p53 levels to accumulate. p53 activity is tightly controlled and regulated at a multiplicity of levels, and the importance of co-factors that influence p53 activity is becoming increasingly evident. Recent studies have highlighted the role of Mdm2 in the control of p53 co-factors. Thus, Mdm2 targets JMY, a p53 co-factor, for ubiquitin-dependent Mdm2 targets JMY, a p53 co-factor, for ubiquitin-dependent proteasomal degradation and in doing so overcomes the ability of JMY to augment the p53 response. These results define a new functional relationship between control of p53 activity and Mdm2, and suggest that transcription co-factors which facilitate the p53 response are important targets through which Mdm2 mediates its oncogenic activity. |
| first_indexed | 2024-03-06T22:14:30Z |
| format | Journal article |
| id | oxford-uuid:52f0e391-067d-4557-89c6-9f2c9112f363 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:14:30Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:52f0e391-067d-4557-89c6-9f2c9112f3632022-03-26T16:28:30ZMdm2 widens its repertoire.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:52f0e391-067d-4557-89c6-9f2c9112f363EnglishSymplectic Elements at Oxford2007Coutts, ALa Thangue, NThe p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects diverse cellular processes which include transcription, DNA synthesis and repair, cell cycle arrest, senescence and apoptosis. The Mdm2 oncoprotein is a primary regulator of p53, mediating p53 control via ubiquitin-dependent proteasomal degradation. During DNA damage, the interaction between p53 and Mdm2 is reduced, which allows p53 levels to accumulate. p53 activity is tightly controlled and regulated at a multiplicity of levels, and the importance of co-factors that influence p53 activity is becoming increasingly evident. Recent studies have highlighted the role of Mdm2 in the control of p53 co-factors. Thus, Mdm2 targets JMY, a p53 co-factor, for ubiquitin-dependent Mdm2 targets JMY, a p53 co-factor, for ubiquitin-dependent proteasomal degradation and in doing so overcomes the ability of JMY to augment the p53 response. These results define a new functional relationship between control of p53 activity and Mdm2, and suggest that transcription co-factors which facilitate the p53 response are important targets through which Mdm2 mediates its oncogenic activity. |
| spellingShingle | Coutts, A La Thangue, N Mdm2 widens its repertoire. |
| title | Mdm2 widens its repertoire. |
| title_full | Mdm2 widens its repertoire. |
| title_fullStr | Mdm2 widens its repertoire. |
| title_full_unstemmed | Mdm2 widens its repertoire. |
| title_short | Mdm2 widens its repertoire. |
| title_sort | mdm2 widens its repertoire |
| work_keys_str_mv | AT couttsa mdm2widensitsrepertoire AT lathanguen mdm2widensitsrepertoire |