Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts

Since 8<sup>th</sup> March 2020 up to the time of writing, we have been producing near real-time weekly estimates of SARS-CoV-2 transmissibility and forecasts of deaths due to COVID-19 for all countries with evidence of sustained transmission, shared online. We also developed a novel heu...

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Main Authors: Bhatia, S, Parag, KV, Wardle, J, Nash, RK, Imai, N, Van Elsland, SL, Lassmann, B, Brownstein, JS, Desai, A, Herringer, M, Sewalk, K, Loeb, SC, Ramatowski, J, Cuomo-Dannenburg, G, Jauneikaite, E, Unwin, HJT, Riley, S, Ferguson, N, Donnelly, C, Cori, A, Nouvellet, P
Format: Journal article
Language:English
Published: Public Library of Science 2023
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author Bhatia, S
Parag, KV
Wardle, J
Nash, RK
Imai, N
Van Elsland, SL
Lassmann, B
Brownstein, JS
Desai, A
Herringer, M
Sewalk, K
Loeb, SC
Ramatowski, J
Cuomo-Dannenburg, G
Jauneikaite, E
Unwin, HJT
Riley, S
Ferguson, N
Donnelly, C
Cori, A
Nouvellet, P
author_facet Bhatia, S
Parag, KV
Wardle, J
Nash, RK
Imai, N
Van Elsland, SL
Lassmann, B
Brownstein, JS
Desai, A
Herringer, M
Sewalk, K
Loeb, SC
Ramatowski, J
Cuomo-Dannenburg, G
Jauneikaite, E
Unwin, HJT
Riley, S
Ferguson, N
Donnelly, C
Cori, A
Nouvellet, P
author_sort Bhatia, S
collection OXFORD
description Since 8<sup>th</sup> March 2020 up to the time of writing, we have been producing near real-time weekly estimates of SARS-CoV-2 transmissibility and forecasts of deaths due to COVID-19 for all countries with evidence of sustained transmission, shared online. We also developed a novel heuristic to combine weekly estimates of transmissibility to produce forecasts over a 4-week horizon. Here we present a retrospective evaluation of the forecasts produced between 8<sup>th</sup> March to 29<sup>th</sup> November 2020 for 81 countries. We evaluated the robustness of the forecasts produced in real-time using relative error, coverage probability, and comparisons with null models. During the 39-week period covered by this study, both the short- and medium-term forecasts captured well the epidemic trajectory across different waves of COVID-19 infections with small relative errors over the forecast horizon. The model was well calibrated with 56.3% and 45.6% of the observations lying in the 50% Credible Interval in 1-week and 4-week ahead forecasts respectively. The retrospective evaluation of our models shows that simple transmission models calibrated using routine disease surveillance data can reliably capture the epidemic trajectory in multiple countries. The medium-term forecasts can be used in conjunction with the short-term forecasts of COVID-19 mortality as a useful planning tool as countries continue to relax public health measures.
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spelling oxford-uuid:53017192-fff1-426b-840f-e59b6e922b932023-11-06T12:17:29ZRetrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecastsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:53017192-fff1-426b-840f-e59b6e922b93EnglishSymplectic ElementsPublic Library of Science2023Bhatia, SParag, KVWardle, JNash, RKImai, NVan Elsland, SLLassmann, BBrownstein, JSDesai, AHerringer, MSewalk, KLoeb, SCRamatowski, JCuomo-Dannenburg, GJauneikaite, EUnwin, HJTRiley, SFerguson, NDonnelly, CCori, ANouvellet, PSince 8<sup>th</sup> March 2020 up to the time of writing, we have been producing near real-time weekly estimates of SARS-CoV-2 transmissibility and forecasts of deaths due to COVID-19 for all countries with evidence of sustained transmission, shared online. We also developed a novel heuristic to combine weekly estimates of transmissibility to produce forecasts over a 4-week horizon. Here we present a retrospective evaluation of the forecasts produced between 8<sup>th</sup> March to 29<sup>th</sup> November 2020 for 81 countries. We evaluated the robustness of the forecasts produced in real-time using relative error, coverage probability, and comparisons with null models. During the 39-week period covered by this study, both the short- and medium-term forecasts captured well the epidemic trajectory across different waves of COVID-19 infections with small relative errors over the forecast horizon. The model was well calibrated with 56.3% and 45.6% of the observations lying in the 50% Credible Interval in 1-week and 4-week ahead forecasts respectively. The retrospective evaluation of our models shows that simple transmission models calibrated using routine disease surveillance data can reliably capture the epidemic trajectory in multiple countries. The medium-term forecasts can be used in conjunction with the short-term forecasts of COVID-19 mortality as a useful planning tool as countries continue to relax public health measures.
spellingShingle Bhatia, S
Parag, KV
Wardle, J
Nash, RK
Imai, N
Van Elsland, SL
Lassmann, B
Brownstein, JS
Desai, A
Herringer, M
Sewalk, K
Loeb, SC
Ramatowski, J
Cuomo-Dannenburg, G
Jauneikaite, E
Unwin, HJT
Riley, S
Ferguson, N
Donnelly, C
Cori, A
Nouvellet, P
Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts
title Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts
title_full Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts
title_fullStr Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts
title_full_unstemmed Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts
title_short Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts
title_sort retrospective evaluation of real time estimates of global covid 19 transmission trends and mortality forecasts
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