Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.

Míreanna comhchosúla

• Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in Gaucher cells.
  de réir: Trapero, A, et al.
  Foilsithe / Cruthaithe: (2011)
• Chaperoning glucocerebrosidase: a therapeutic strategy for both Gaucher disease and Parkinsonism
  de réir: Benjamin McMahon, et al.
  Foilsithe / Cruthaithe: (2016-01-01)
• Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.
  de réir: Wang, G, et al.
  Foilsithe / Cruthaithe: (2009)
• Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease.
  de réir: Wang, G, et al.
  Foilsithe / Cruthaithe: (2012)
• Effect of macrophage-targeted glucocerebrosidase(alglucerase) on hypolipidaemia of type 1 Gaucher disease(GD)
  de réir: Mistry, P, et al.
  Foilsithe / Cruthaithe: (1997)