Development of advanced three-dimensional tumour models for anti-cancer drug testing

Development of advanced three-dimensional tumour models for anti-cancer drug testing

Animal testing is still the common method to test the efficacy of new drugs, but tissue engineered in vitro models are becoming more acceptable for replacing and reducing animal testing in anti-cancer drug screening by developing <em>in vitro</em> three-dimensional (3D) tumour models for...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Wan, X
Awduron Eraill:	Cui, Z
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2014
Pynciau:	Medical Sciences Oncology Medical Engineering Biomedical engineering Pharmacology Cell Biology (see also Plant sciences) Vascular research Life Sciences High-Throughput Screening Tumours

Eitemau Tebyg

Targeting cell adhesion as a method of sensitising metastatic tumour cells to TRAIL-induced apoptosis
gan: Phipps, L
Cyhoeddwyd: (2011)

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
gan: Knowles, H, et al.
Cyhoeddwyd: (2008)

Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance
gan: Ledaki, I
Cyhoeddwyd: (2013)

Reporting of prognostic studies of tumour markers: a review of published articles in relation to REMARK guidelines
gan: Mallett, S, et al.
Cyhoeddwyd: (2010)

Functional analysis of cancer/testis antigens in human cancer
gan: Pagotto, A
Cyhoeddwyd: (2013)

E2F7: a member of the E2F family with a novel mechanism of transcriptional repression
gan: Kesoglidou, PX
Cyhoeddwyd: (2012)

Regulation of E2F-1 by methylation and NEDDylation
gan: Loftus, S, et al.
Cyhoeddwyd: (2012)

The role of p53 in hypoxia-induced apoptosis
gan: Poole, R
Cyhoeddwyd: (2010)

QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data
gan: Colella, S, et al.
Cyhoeddwyd: (2007)

Electrostatic and functional analysis of the seven-bladed WD beta-propellers
gan: Valeyev, N, et al.
Cyhoeddwyd: (2008)

Disease model distortion in association studies
gan: Vukcevic, D, et al.
Cyhoeddwyd: (2011)

A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
gan: Howie, B, et al.
Cyhoeddwyd: (2009)

A robust clustering algorithm for identifying problematic samples in genome-wide association studies
gan: Bellenguez, C, et al.
Cyhoeddwyd: (2012)

Studies on HIF hydroxylases
gan: Webb, J
Cyhoeddwyd: (2008)

Cellular models for characterisation of MINA53, a 2-oxoglutarate-dependent dioxygenase
gan: Zayer, A
Cyhoeddwyd: (2012)

Tumour-stroma interaction in pancreatic cancer
gan: Lunardi, S
Cyhoeddwyd: (2013)

Trials in primary care: statistical issues in the design, conduct and evaluation of complex interventions
gan: Lancaster, G, et al.
Cyhoeddwyd: (2010)

Targeting polymer coated adenovirus to tumour-associated vasculature
gan: Bachtarzi, H
Cyhoeddwyd: (2010)

The influence of BRCA1's ubiquitin ligase activity on cell motility
gan: Sengupta, S
Cyhoeddwyd: (2014)

Assessing the role of ADAM10 in Trastuzumab treatment and resistance
gan: Feldinger, K
Cyhoeddwyd: (2012)

Mucosal associated invariant T cells and related CD161 expressing T lymphocytes
gan: Fergusson, J, et al.
Cyhoeddwyd: (2015)

Structure-function studies of fibronectin domains in the human endometrium
gan: Mok, M, et al.
Cyhoeddwyd: (2008)

Reweighting methods in high dimensional regression
gan: Fang, Z
Cyhoeddwyd: (2012)

The role of Topoisomerase II in replication in mammalian cells
gan: Muftic, D
Cyhoeddwyd: (2011)

HR23B, a biomarker for HDAC inhibitors
gan: Khan, OA
Cyhoeddwyd: (2013)

Some aspects of complex statistical dependencies
gan: Kartsonaki, C
Cyhoeddwyd: (2014)

Synonymous codon usage influences the local protein structure observed
gan: Saunders, R, et al.
Cyhoeddwyd: (2010)

Markov fields and log-linear interaction models for contingency tables
gan: Darroch, J, et al.
Cyhoeddwyd: (1980)

Models and software for improving the profitability of pharmaceutical research
gan: Qu, S
Cyhoeddwyd: (2011)

Hyper Markov laws in the statistical analysis of decomposable graphical models
gan: Dawid, A, et al.
Cyhoeddwyd: (1993)

Graphical models for associations between variables, some of which are quantitative and some qualitative
gan: Lauritzen, S, et al.
Cyhoeddwyd: (1989)

Graphical models for genetic analyses
gan: Lauritzen, S, et al.
Cyhoeddwyd: (2003)

Some problems in the theory & application of graphical models
gan: Roddam, A
Cyhoeddwyd: (1999)

A coalescent dual process in a Moran model with genic selection, and the lambda coalescent limit
gan: Etheridge, A, et al.
Cyhoeddwyd: (2010)

How threshold behaviour affects the use of subgraphs for network comparison
gan: Rito, T, et al.
Cyhoeddwyd: (2010)

An approximate sampling formula under genetic hitchhiking
gan: Etheridge, A, et al.
Cyhoeddwyd: (2006)

A Bayesian cost-benefit approach to sample size determination and evaluation in clinical trials
gan: Kikuchi, T
Cyhoeddwyd: (2011)

Human orthologues of Saccharomyces cerevisiae Trf4/5 non-canonical poly(A) polymerases
gan: Gibson, K
Cyhoeddwyd: (2011)

Course of distress in breast cancer patients, their partners, and matched control couples
gan: Hinnen, C, et al.
Cyhoeddwyd: (2008)

Pathways for glycoprotein degradation in mammalian cells
gan: Kukushkin, N, et al.
Cyhoeddwyd: (2011)