Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body
Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been a matter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of N...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Cell Press
2017
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| _version_ | 1797068838885392384 |
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| author | Annese, V Navarro-Guerrero, E Rodríguez-Prieto, I Pardal, R |
| author_facet | Annese, V Navarro-Guerrero, E Rodríguez-Prieto, I Pardal, R |
| author_sort | Annese, V |
| collection | OXFORD |
| description | Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been a matter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of NCSCs retain this plasticity is largely unknown. Herein, we describe that neural-crest-derived adult carotid body stem cells (CBSCs) are able to undergo endothelial differentiation in addition to their reported role in neurogenesis, contributing to both neurogenic and angiogenic processes taking place in the organ during acclimatization to hypoxia. Moreover, CBSC conversion into vascular cell types is hypoxia inducible factor (HIF) dependent and sensitive to hypoxia-released vascular cytokines such as erythropoietin. Our data highlight a remarkable physiological plasticity in an adult population of tissue-specific stem cells and could have impact on the use of these cells for cell therapy. |
| first_indexed | 2024-03-06T22:15:49Z |
| format | Journal article |
| id | oxford-uuid:535a7735-fcf9-4ad0-affe-428a95fbd615 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:15:49Z |
| publishDate | 2017 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:535a7735-fcf9-4ad0-affe-428a95fbd6152022-03-26T16:31:04ZPhysiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid bodyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:535a7735-fcf9-4ad0-affe-428a95fbd615EnglishSymplectic Elements at OxfordCell Press2017Annese, VNavarro-Guerrero, ERodríguez-Prieto, IPardal, RAdult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been a matter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of NCSCs retain this plasticity is largely unknown. Herein, we describe that neural-crest-derived adult carotid body stem cells (CBSCs) are able to undergo endothelial differentiation in addition to their reported role in neurogenesis, contributing to both neurogenic and angiogenic processes taking place in the organ during acclimatization to hypoxia. Moreover, CBSC conversion into vascular cell types is hypoxia inducible factor (HIF) dependent and sensitive to hypoxia-released vascular cytokines such as erythropoietin. Our data highlight a remarkable physiological plasticity in an adult population of tissue-specific stem cells and could have impact on the use of these cells for cell therapy. |
| spellingShingle | Annese, V Navarro-Guerrero, E Rodríguez-Prieto, I Pardal, R Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body |
| title | Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body |
| title_full | Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body |
| title_fullStr | Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body |
| title_full_unstemmed | Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body |
| title_short | Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body |
| title_sort | physiological plasticity of neural crest derived stem cells in the adult mammalian carotid body |
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