Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAART.

Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAART.

OBJECTIVE: To determine whether long-term HAART in chronic HIV-1 infection restores fully functional Mycobacterium tuberculosis (MTB)-specific CD4 T-cell responses. DESIGN: A cross-sectional study of HIV-1-seropositive subjects on continuous HAART for over one year with CD4 cell counts greater than...

Full description

Bibliographic Details
Main Authors:	Sutherland, R, Yang, H, Scriba, T, Ondondo, B, Robinson, N, Conlon, C, Suttill, A, Mcshane, H, Fidler, S, McMichael, A, Dorrell, L
Format:	Journal article
Language:	English
Published:	2006

Similar Items

pTHr.HIVA and MVA.HIVA vaccines (gag p24/p17) augment CD4+T cell responses in chronically infected HIV-1 patients on HAART
by: Ondondo, B, et al.
Published: (2005)

Normal expression of IFN-gammaR in four patients with uncommon mycobacterial infection phenotypes
by: M.T. Rugeles, et al.
Published: (2004-09-01)

Comprehensive analysis of HIV Gag-specific IFN-gamma response in HIV-1- and HIV-2-infected asymptomatic patients from a clinical cohort in The Gambia.
by: Ondondo, B, et al.
Published: (2008)

Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment.
by: Pathan, A, et al.
Published: (2001)

Human CD8+ CTL specific for the mycobacterial major secreted antigen 85A.
by: Smith, S, et al.
Published: (2000)

Peripheral IFN-ɣ Production after Blood Stimulation with Different Mycobacterial Antigens in Goats Vaccinated against Paratuberculosis
by: Miguel Fernández, et al.
Published: (2022-10-01)

Immunisation with recombinant modified vaccinia virus Ankara expressing HIV-1 gag in HIV-1-infected subjects stimulates broad functional CD4+ T cell responses.
by: Ondondo, B, et al.
Published: (2006)

Detection of broad functional gag-specific CD4+T cell responses in HIV-1-infected subjects following therapeutic immunization with rMVA expressing an HIV-1 gag immunogen
by: Ondondo, B, et al.
Published: (2006)

The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis.
by: Lauw, F, et al.
Published: (2000)

Onchocerciasis modulates the immune response to mycobacterial antigens.
by: Stewart, G, et al.
Published: (1999)

Safety and tolerability of recombinant modified vaccinia virus Ankara expressing an HIV-1 gag/multiepitope immunogen (MVA.HIVA) in HIV-1-infected persons receiving combination antiretroviral therapy.
by: Dorrell, L, et al.
Published: (2007)

The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo.
by: Ota, M, et al.
Published: (2007)

Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load.
by: Millington, K, et al.
Published: (2007)

Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.
by: Dorrell, L, et al.
Published: (2006)

Identification of novel mycobacterial antigens presented by MHC-I and -II by immunopeptidomics for vaccines against tuberculosis
by: Bettencourt, P, et al.
Published: (2019)

High dose interferon-alpha induction therapy is associated with a profound loss of IL-2 and IFN-gamma secreting HCV specific T-cells
by: Gelderblom, H, et al.
Published: (2007)

Mycobacterial Virulence Factors: Surface-Exposed Lipids and Secreted Proteins
by: Angel Ly, et al.
Published: (2020-06-01)

High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease.
by: Pathan, A, et al.
Published: (2000)

Development of a primate model for tuberculosis vaccine research: IFN-gamma responses induced by BCG vaccination and M-tuberculosis infection in macaques
by: Dowall, S, et al.
Published: (2007)

The impact of HIV on maternal morbidity in the Pre-HAART era in Uganda.
by: Nuwagaba-Biribonwoha, H, et al.
Published: (2012)

The cross-species mycobacterial growth inhibition assay (MGIA) project 2010-2014
by: Brennan, M, et al.
Published: (2017)

Optimising immunogenicity with viral vectors: mixing MVA and HAdV-5 expressing the mycobacterial antigen Ag85A in a single injection
by: Betts, G, et al.
Published: (2012)

Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.
by: Tone, M, et al.
Published: (1997)

Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions.
by: Salio, M, et al.
Published: (2003)

T-cell response to my mycobacterial antigens in lepromatous and tuberculoid leprosy
by: Marie Anne Bach
Published: (1987-01-01)

Mechanical Forces between Mycobacterial Antigen 85 Complex and Fibronectin
by: Albertus Viljoen, et al.
Published: (2020-03-01)

Recombinant mycobacterial DNA-binding protein 1 with post-translational modifications boosts IFN-gamma production from BCG-vaccinated individuals’ blood cells in combination with CpG-DNA
by: Yuriko Ozeki, et al.
Published: (2024-04-01)

Secretion of IFN-γ by specific T cells in HCMV infection
by: Hanying Liang, et al.
Published: (2024-03-01)

Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients
by: Leonardo Sorrentino, et al.
Published: (2023-03-01)

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth
by: Fletcher, H, et al.
Published: (2009)

Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis.
by: Lauw, F, et al.
Published: (1999)

HIV/HCV coinfection, HAART, and liver-related mortality.
by: Sabin, C, et al.
Published: (2004)

The impact of HIV-1 subtype on the clinical response on HAART.
by: Frater, J
Published: (2002)

HAART, ocular opportunistic infections, ocular malignancies, and uveitis
by: Rujittika Mungmunpuntipantip, et al.
Published: (2024-01-01)

Causes of hypercalcemia in people living with HIV in the HAART era
by: Arkom Nongnuch, et al.
Published: (2020-10-01)

Development and application of the direct mycobacterial growth inhibition assay: a systematic review
by: Painter, H, et al.
Published: (2024)

Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia
by: Anemut Tilahun, et al.
Published: (2022-11-01)

IFN gamma and CXCR-1 gene polymorphisms in idiopathic bronchiectasis.
by: Boyton, R, et al.
Published: (2006)

Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine.
by: Dorrell, L, et al.
Published: (2005)

Adverse perinatal outcomes associated with HAART and monotherapy: systematic review and meta-analysis
by: Portwood, C, et al.
Published: (2022)