Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012
<p style="text-align:justify;"> SETTING: Few studies have shown the operational feasibility, safety, tolerability, or outcomes of multidrug-resistant latent tuberculous infection (MDR LTBI) treatment. After two simultaneous multidrug-resistant tuberculosis (MDR-TB) outbreaks in Chuu...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
International Union Against Tuberculosis and Lung Disease
2014
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| _version_ | 1797068871637663744 |
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| author | Bamrah, S Brostrom, R Dorina, F Setik, L Song, R Kawamura, L Heetderks, A Mase, S |
| author_facet | Bamrah, S Brostrom, R Dorina, F Setik, L Song, R Kawamura, L Heetderks, A Mase, S |
| author_sort | Bamrah, S |
| collection | OXFORD |
| description | <p style="text-align:justify;"> SETTING: Few studies have shown the operational feasibility, safety, tolerability, or outcomes of multidrug-resistant latent tuberculous infection (MDR LTBI) treatment. After two simultaneous multidrug-resistant tuberculosis (MDR-TB) outbreaks in Chuuk, Federated States of Micronesia, infected contacts were offered a 12-month fluoroquinolone (FQ) based MDR LTBI treatment regimen. DESIGN: Between January 2009 and February 2012, 119 contacts of MDR-TB patients were followed using a prospective observational study design. After MDR-TB disease was excluded, 12 months of daily FQ-based preventive treatment of MDR LTBI was provided by directly observed therapy. RESULTS: Among the 119 infected contacts, 15 refused, while 104 began treatment for MDR LTBI. Of the 104 who initiated treatment, 93 (89%) completed treatment, while 4 contacts discontinued due to adverse effects. None of the 104 contacts who undertook MDR LTBI treatment of any duration developed MDR-TB disease; however, 3 of 15 contacts who refused and 15 unidentified contacts developed MDR-TB disease. CONCLUSION: Providing treatment for MDR LTBI can be accomplished in a resource-limited setting, and contributed to preventing MDR-TB disease. The Chuuk TB program implemented treatment of MDR LTBI with an 89% completion rate. The MDR LTBI regimens were safe and well tolerated, and no TB cases occurred among persons treated for MDR LTBI. </p> |
| first_indexed | 2024-03-06T22:16:13Z |
| format | Journal article |
| id | oxford-uuid:53787e42-5396-4908-97ca-9766da55143d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:16:13Z |
| publishDate | 2014 |
| publisher | International Union Against Tuberculosis and Lung Disease |
| record_format | dspace |
| spelling | oxford-uuid:53787e42-5396-4908-97ca-9766da55143d2022-03-26T16:31:53ZTreatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:53787e42-5396-4908-97ca-9766da55143dEnglishSymplectic Elements at OxfordInternational Union Against Tuberculosis and Lung Disease2014Bamrah, SBrostrom, RDorina, FSetik, LSong, RKawamura, LHeetderks, AMase, S <p style="text-align:justify;"> SETTING: Few studies have shown the operational feasibility, safety, tolerability, or outcomes of multidrug-resistant latent tuberculous infection (MDR LTBI) treatment. After two simultaneous multidrug-resistant tuberculosis (MDR-TB) outbreaks in Chuuk, Federated States of Micronesia, infected contacts were offered a 12-month fluoroquinolone (FQ) based MDR LTBI treatment regimen. DESIGN: Between January 2009 and February 2012, 119 contacts of MDR-TB patients were followed using a prospective observational study design. After MDR-TB disease was excluded, 12 months of daily FQ-based preventive treatment of MDR LTBI was provided by directly observed therapy. RESULTS: Among the 119 infected contacts, 15 refused, while 104 began treatment for MDR LTBI. Of the 104 who initiated treatment, 93 (89%) completed treatment, while 4 contacts discontinued due to adverse effects. None of the 104 contacts who undertook MDR LTBI treatment of any duration developed MDR-TB disease; however, 3 of 15 contacts who refused and 15 unidentified contacts developed MDR-TB disease. CONCLUSION: Providing treatment for MDR LTBI can be accomplished in a resource-limited setting, and contributed to preventing MDR-TB disease. The Chuuk TB program implemented treatment of MDR LTBI with an 89% completion rate. The MDR LTBI regimens were safe and well tolerated, and no TB cases occurred among persons treated for MDR LTBI. </p> |
| spellingShingle | Bamrah, S Brostrom, R Dorina, F Setik, L Song, R Kawamura, L Heetderks, A Mase, S Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012 |
| title | Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012 |
| title_full | Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012 |
| title_fullStr | Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012 |
| title_full_unstemmed | Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012 |
| title_short | Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012 |
| title_sort | treatment for ltbi in contacts of mdr tb patients federated states of micronesia 2009 2012 |
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