Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study.
IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(2...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797068879361474560 |
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| author | Lavrenkov, K Singh, S Christian, J Partridge, M Nioutsikou, E Cook, G Bedford, J Brada, M |
| author_facet | Lavrenkov, K Singh, S Christian, J Partridge, M Nioutsikou, E Cook, G Bedford, J Brada, M |
| author_sort | Lavrenkov, K |
| collection | OXFORD |
| description | IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung. |
| first_indexed | 2024-03-06T22:16:20Z |
| format | Journal article |
| id | oxford-uuid:53820ea6-d26b-4b5c-a7c9-f22dd8b4e7cf |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:16:20Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:53820ea6-d26b-4b5c-a7c9-f22dd8b4e7cf2022-03-26T16:32:05ZEffective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:53820ea6-d26b-4b5c-a7c9-f22dd8b4e7cfEnglishSymplectic Elements at Oxford2009Lavrenkov, KSingh, SChristian, JPartridge, MNioutsikou, ECook, GBedford, JBrada, MIMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung. |
| spellingShingle | Lavrenkov, K Singh, S Christian, J Partridge, M Nioutsikou, E Cook, G Bedford, J Brada, M Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study. |
| title | Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study. |
| title_full | Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study. |
| title_fullStr | Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study. |
| title_full_unstemmed | Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study. |
| title_short | Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study. |
| title_sort | effective avoidance of a functional spect perfused lung using intensity modulated radiotherapy imrt for non small cell lung cancer nsclc an update of a planning study |
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