Structures of the Plasmodium falciparum heat-shock protein 70-x ATPase domain in complex with chemical fragments identify conserved and unique binding sites

Structures of the Plasmodium falciparum heat-shock protein 70-x ATPase domain in complex with chemical fragments identify conserved and unique binding sites

Plasmodium falciparum invades erythrocytes and extensively modifies them in a manner that increases the virulence of this malaria parasite. A single heat-shock 70 kDa-type chaperone, PfHsp70-x, is among the parasite proteins exported to the host cell. PfHsp70-x assists in the formation of a key prot...

书目详细资料
Main Authors:	Mohamad, N, Kantsadi, A, Vakonakis, I, O'Donoghue, A
格式:	Journal article
语言:	English
出版:	International Union of Crystallography 2021

相似书籍

Structure of the Plasmodium falciparum heat shock protein 70-x substrate binding domain
由: Schmidt, J, et al.
出版: (2020)

The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel small molecule binding site
由: Machin, J, et al.
出版: (2019)

The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site
由: Jonathan M. Machin, et al.
出版: (2019-12-01)

Identification of an exported heat shock protein 70 in Plasmodium falciparum
由: Grover Manish, et al.
出版: (2013-01-01)

The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite
由: Day, J, et al.
出版: (2019)

Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope.
由: Mayer, C, et al.
出版: (2012)

Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
由: Yassin Ben-Khoud, et al.
出版: (2023-03-01)

Iso-mukaadial acetate and ursolic acid acetate bind to Plasmodium Falciparum heat shock protein 70: towards targeting parasite protein folding pathway
由: Francis Opoku, et al.
出版: (2024-03-01)

Supporting data on characterisation of linker switch mutants of Plasmodium falciparum heat shock protein 110 and canonical Hsp70
由: Graham Chakafana, et al.
出版: (2021-08-01)

The structure of the cysteine-rich domain of Plasmodium falciparum P113 identifies the location of the RH5 binding site
由: Campeotto, I, et al.
出版: (2020)

Identification of Plasmodium falciparum HSP70-2 as a resident of the Plasmodium export compartment
由: Gladys T. Cortés, et al.
出版: (2020-06-01)

No <it>PfATPase6 </it>S769N mutation found in <it>Plasmodium falciparum </it>isolates from China
由: Wu Song, et al.
出版: (2008-07-01)

Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites
由: Iyer, Jayasree K., et al.
出版: (2011)

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.
由: Xiaohong Gao, et al.
出版: (2008-07-01)

Inhibition of Plasmodium falciparum Hsp70-Hop partnership by 2-phenylthynesulfonamide
由: Tshifhiwa Muthelo, et al.
出版: (2022-09-01)

Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development.
由: Caroline Kulangara, et al.
出版: (2009-05-01)

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein.
由: Tawanda Zininga, et al.
出版: (2015-01-01)

A COVID moonshot: assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy
由: Kantsadi, AL, et al.
出版: (2021)

Preparation of pure and intact <it>Plasmodium falciparum</it> plasma membrane vesicles and partial characterisation of the plasma membrane ATPase
由: Smith Pete J, et al.
出版: (2002-04-01)

Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506
由: Kotaka, Masayo, et al.
出版: (2012)

The Plasmodium falciparum exported J domain proteins fine-tune human and malarial Hsp70s: pathological exploitation of proteostasis machinery
由: Shaikha Y. Almaazmi, et al.
出版: (2023-06-01)

The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site.
由: Berendt, A, et al.
出版: (1992)

Plasmodium falciparum YTH2 Domain Binds to m6A-Containing mRNA and Regulates Translation
由: Gayathri Govindaraju, et al.
出版: (2021-12-01)

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.
由: Tony Triglia, et al.
出版: (2011-06-01)

Characterization of the substrate binding site of an iron detoxifying membrane transporter from Plasmodium falciparum
由: Pragya Sharma, et al.
出版: (2021-06-01)

In silico identification of modulators of J domain protein-Hsp70 interactions in Plasmodium falciparum: a drug repurposing strategy against malaria
由: Harpreet Singh, et al.
出版: (2023-08-01)

Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35)
由: Kang, Cong Bao, et al.
出版: (2012)

Identification of a novel and unique transcription factor in the intraerythrocytic stage of Plasmodium falciparum.
由: Kanako Komaki-Yasuda, et al.
出版: (2013-01-01)

Genetic analysis reveals unique characteristics of Plasmodium falciparum parasite populations in Haiti
由: Rachel F. Daniels, et al.
出版: (2020-10-01)

Possible pitfalls in the identification of glycophorin-binding proteins of Plasmodium falciparum.
由: van Schravendijk, MR, et al.
出版: (1987)

Binding of Plasmodium falciparum to CD36 can be shielded by the glycocalyx
由: Casper Hempel, et al.
出版: (2017-05-01)

The relationship between protein domains and homopeptides in the Plasmodium falciparum proteome
由: Yue Wang, et al.
出版: (2020-10-01)

The <it>MB2 </it>gene family of <it>Plasmodium </it>species has a unique combination of S1 and GTP-binding domains
由: Ogunjumo Oluwasanmi, et al.
出版: (2004-06-01)

Detection of point mutation in Plasmodium falciparum ATPase6 gene associated with artemisinin resistance from Assam and Arunachal Pradesh
由: Jitendra Sharma, et al.
出版: (2014-12-01)

Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity.
由: Ronan Jambou, et al.
出版: (2010-02-01)

The 10 kDa domain of human erythrocyte protein 4.1 binds the <it>Plasmodium falciparum </it>EBA-181 protein
由: Coetzer Theresa L, et al.
出版: (2006-11-01)

Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein
由: Tiantian Fang, et al.
出版: (2019-01-01)

Intraerythrocytic polyubiquitin expression in Plasmodium falciparum is subjected to developmental and heat-shock control.
由: Horrocks, P, et al.
出版: (2000)

Controlling drug resistance by targeting Plasmodium falciparum heat shock protein 70-1, a chaperone at the centre of protein quality control mechanism: a review
由: Douglas A. M. Ruhwaya, et al.
出版: (2023-12-01)

Plasmodium falciparum Hep1 Is Required to Prevent the Self Aggregation of PfHsp70-3.
由: David O Nyakundi, et al.
出版: (2016-01-01)