Structural analysis uncovers lipid-binding properties of Notch ligands.

Structural analysis uncovers lipid-binding properties of Notch ligands.

The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system activation, and angiogenesis. Signals are initiated by extracellular interactions of the Notch receptor with Delta/Serrate/Lag-2 (DSL) ligands,...

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Bibliographic Details
Main Authors:	Chillakuri, C, Sheppard, D, Ilagan, M, Holt, L, Abbott, F, Liang, S, Kopan, R, Handford, P, Lea, S
Format:	Journal article
Language:	English
Published:	2013

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