Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

N(ε)-Methylations of histone lysine residues play critical roles in cell biology by "marking" chromatin for transcriptional activation or repression. Lysine demethylases reverse N(ε)-methylation in a sequence- and methylation-selective manner. The determinants of sequence selectivity for h...

Повний опис

Бібліографічні деталі
Автори: Hillringhaus, L, Yue, W, Rose, N, Ng, S, Gileadi, C, Loenarz, C, Bello, S, Bray, J, Schofield, C, Oppermann, U
Формат: Journal article
Мова:English
Опубліковано: 2011

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