A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID
Incubation of (2S)-5-amino-(2′-oxoazetidin-1′-yl)pentanoic acid with clavaminic acid synthase gave (2S)-5-amino-2-(2′-oxoazetidin- 1′-yl)pent-3,4-enoic acid as the major product, together with a small amount of proclayaminic acid; modification of the amino group to the guanyl group biased the mode o...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
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1993
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| _version_ | 1797068932300931072 |
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| author | Baldwin, J Lloyd, M Whason, B Schofield, C Elson, S Baggaley, K Nicholson, N |
| author_facet | Baldwin, J Lloyd, M Whason, B Schofield, C Elson, S Baggaley, K Nicholson, N |
| author_sort | Baldwin, J |
| collection | OXFORD |
| description | Incubation of (2S)-5-amino-(2′-oxoazetidin-1′-yl)pentanoic acid with clavaminic acid synthase gave (2S)-5-amino-2-(2′-oxoazetidin- 1′-yl)pent-3,4-enoic acid as the major product, together with a small amount of proclayaminic acid; modification of the amino group to the guanyl group biased the mode of reactivity from desaturation to hydroxylation. |
| first_indexed | 2024-03-06T22:17:07Z |
| format | Journal article |
| id | oxford-uuid:53c06c3f-c1ff-454a-b7ed-263e7895e967 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:17:07Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:53c06c3f-c1ff-454a-b7ed-263e7895e9672022-03-26T16:33:42ZA SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACIDJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:53c06c3f-c1ff-454a-b7ed-263e7895e967Symplectic Elements at Oxford1993Baldwin, JLloyd, MWhason, BSchofield, CElson, SBaggaley, KNicholson, NIncubation of (2S)-5-amino-(2′-oxoazetidin-1′-yl)pentanoic acid with clavaminic acid synthase gave (2S)-5-amino-2-(2′-oxoazetidin- 1′-yl)pent-3,4-enoic acid as the major product, together with a small amount of proclayaminic acid; modification of the amino group to the guanyl group biased the mode of reactivity from desaturation to hydroxylation. |
| spellingShingle | Baldwin, J Lloyd, M Whason, B Schofield, C Elson, S Baggaley, K Nicholson, N A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID |
| title | A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID |
| title_full | A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID |
| title_fullStr | A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID |
| title_full_unstemmed | A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID |
| title_short | A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID |
| title_sort | substrate analog study on clavaminic acid synthase possible clues to the biosynthetic origin of proclavamic acid |
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