Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases

Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases

Antibodies can block immune receptor engagement or trigger the receptor machinery to initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically excluding large receptor-type protein tyrosine phosphatases (RPTPs) such as CD45 from sites of receptor engagement. An agoni...

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Hlavní autoři: Lippert, AH, Paluch, C, Gaglioni, M, Vuong, MT, McColl, J, Jenkins, E, Fellermeyer, M, Clarke, J, Sharma, S, Moreira da Silva, S, Akkaya, B, Anzilotti, C, Morgan, SH, Jessup, CF, Koerbel, M, Gileadi, U, Leitner, J, Knox, R, Chirifu, M, Huo, J, Yu, S, Ashman, N, Lui, Y, Wilkinson, I, Attfield, KE, Fugger, L, Robertson, NJ, Lynch, CJ, Murray, L, Steinberger, P, Santos, AM, Lee, SF, Cornall, RJ, Klenerman, D, Davis, SJ
Médium: Journal article
Jazyk:English
Vydáno: Cell Press 2024

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