Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism
Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making t...
| Principais autores: | , , , , , , |
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| Formato: | Journal article |
| Publicado em: |
Wiley
2017
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| _version_ | 1826272756376797184 |
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| author | Chong, T Bonnelle, V Veromann, K Juurmaa, J Taba, P Plant, O Husain, M |
| author_facet | Chong, T Bonnelle, V Veromann, K Juurmaa, J Taba, P Plant, O Husain, M |
| author_sort | Chong, T |
| collection | OXFORD |
| description | Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained. |
| first_indexed | 2024-03-06T22:17:37Z |
| format | Journal article |
| id | oxford-uuid:53effe08-0e24-4122-809c-5d25b076cc96 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:17:37Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:53effe08-0e24-4122-809c-5d25b076cc962022-03-26T16:34:43ZDissociation of reward and effort sensitivity in methcathinone-induced ParkinsonismJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:53effe08-0e24-4122-809c-5d25b076cc96Symplectic Elements at OxfordWiley2017Chong, TBonnelle, VVeromann, KJuurmaa, JTaba, PPlant, OHusain, MMethcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained. |
| spellingShingle | Chong, T Bonnelle, V Veromann, K Juurmaa, J Taba, P Plant, O Husain, M Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism |
| title | Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism |
| title_full | Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism |
| title_fullStr | Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism |
| title_full_unstemmed | Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism |
| title_short | Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism |
| title_sort | dissociation of reward and effort sensitivity in methcathinone induced parkinsonism |
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