Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo
<p style="text-align:justify;">Background: Gene delivery vectors based on poly(L‐lysine) and DNA (pLL/DNA complexes) have limited use for targeted systemic application in vivo since they bind cells and proteins non‐specifically. In this study we have attempted to form folate‐targeted...
| Autores principales: | , , , , |
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| Formato: | Journal article |
| Publicado: |
Wiley
2002
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