Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo

Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo

<p style="text-align:justify;">Background: Gene delivery vectors based on poly(L‐lysine) and DNA (pLL/DNA complexes) have limited use for targeted systemic application in vivo since they bind cells and proteins non‐specifically. In this study we have attempted to form folate‐targeted...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Ward, C, Pechar, M, Oupicky, D, Ulbrich, K, Seymour, L
Формат:	Journal article
Хэвлэсэн:	Wiley 2002

Ижил төстэй зүйлс

Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
-н: Dash, P, зэрэг
Хэвлэсэн: (2000)

Conjugation of Folate via Gelonin Carbohydrate Residues Retains Ribosomal-inactivating Properties of the Toxin and Permits Targeting to Folate Receptor Positive Cells
-н: Atkinson, S, зэрэг
Хэвлэсэн: (2001)

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
-н: Fisher, K, зэрэг
Хэвлэсэн: (2001)

Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.
-н: Zhou, Q, зэрэг
Хэвлэсэн: (2005)

Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA
-н: Howard, K, зэрэг
Хэвлэсэн: (2000)

Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
-н: Oupicky, D, зэрэг
Хэвлэсэн: (2002)

Surface modification of AAV5 permits polymer coating and inhibition of infection, with tropism restored by covalent linkage of new ligands
-н: Carlisle, R, зэрэг
Хэвлэсэн: (2004)

Application of Hydrophilic Polymers to the Preparation of Prolonged-Release Minitablets with Bromhexine Hydrochloride and Bisoprolol Fumarate
-н: Agata Grzejdziak, зэрэг
Хэвлэсэн: (2024-08-01)

Computational insights into multivalently binding polymers
-н: Zumbro, Emiko.
Хэвлэсэн: (2021)

Folate-Functionalization Enhances Cytotoxicity of Multivalent DNA Nanocages on Triple-Negative Breast Cancer Cells
-н: Valeria Unida, зэрэг
Хэвлэсэн: (2022-11-01)

Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.
-н: Oupický, D, зэрэг
Хэвлэсэн: (2001)

A Viral Platform for Chemical Modification and Multivalent Display
-н: Peabody David S
Хэвлэсэн: (2003-07-01)

Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations
-н: Reschel, T, зэрэг
Хэвлэсэн: (2002)

Subhourly rainfall in a convection-permitting model
-н: Edmund P Meredith, зэрэг
Хэвлэсэн: (2020-01-01)

Super-hydrophilic zwitterionic polymer surface modification facilitates liquid transportation of microfluidic sweat sensors
-н: Fu, Fanfan, зэрэг
Хэвлэсэн: (2022)

A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression
-н: Fisher, KD, зэрэг
Хэвлэсэн: (2000)

Hydrophilic polymers : performance with environmental acceptance /
-н: Glass, J. E. (J. Edward), 1937-, зэрэг
Хэвлэсэн: (1996)

Hydrophilic polymers in potting soil mix
-н: T Furuta, зэрэг
Хэвлэсэн: (1988-05-01)

Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds
-н: Michaela Mühlberg, зэрэг
Хэвлэсэн: (2015-05-01)

DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers
-н: Oupický, D, зэрэг
Хэвлэсэн: (2000)

Modification of surface hydrophilicity of dental materials by ozone
-н: Ira Artilia
Хэвлэсэн: (2019-07-01)

Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug Doxorubicin
-н: Pechar, M, зэрэг
Хэвлэсэн: (2000)

Macromodelling of a PLL system
-н: Xue, Xiaoqing.
Хэвлэсэн: (2009)

Optimization of PLL frequency synthesizer
-н: G. A. Koshuk, зэрэг
Хэвлэсэн: (2019-06-01)

T-PLL Presenting with an Indolent Course
-н: Arsa Thammahong, зэрэг
Хэвлэсэн: (2024-01-01)

X-Band PLL Synthesizer
-н: P. Kutin, зэрэг
Хэвлэсэн: (2006-04-01)

PLL design and investigation in CMOS
-н: Jevgenij Charlamov
Хэвлэсэн: (2010-02-01)

Influence of Binding Site Affinity Patterns on Binding of Multivalent Polymers
-н: Zumbro, Emiko, зэрэг
Хэвлэсэн: (2021)

Structure-conductivity studies in polymer electrolytes containing multivalent cations /
-н: 263346 Madzlan Aziz
Хэвлэсэн: (1996)

Influence of Binding Site Affinity Patterns on Binding of Multivalent Polymers
-н: Emiko Zumbro, зэрэг
Хэвлэсэн: (2020-05-01)

SPECTROSCOPIC STUDIES OF HETEROBIMETALLIC ADDUCTS OF TIN WITH Mn(ll), Co(ll), Cu(ll) AND Zn(ll)
-н: Khan, Tahir Ali, зэрэг
Хэвлэсэн: (1996-04-01)

INFLUENCE OF ACID MODIFICATION ON HYDROPHOBIC/HYDROPHILIC PROPERTIES OF CLINOPTILOLITE
-н: Yu.V. Bondar
Хэвлэсэн: (2023-10-01)

Pretreatment and Membrane Hydrophilic Modification to Reduce Membrane Fouling
-н: Huaqiang Chu, зэрэг
Хэвлэсэн: (2013-09-01)

Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation
-н: Zumbro, Emiko, зэрэг
Хэвлэсэн: (2022)

Review of Multivalent Metal Ion Transport in Inorganic and Solid Polymer Electrolytes
-н: Lauren F. O’Donnell, зэрэг
Хэвлэсэн: (2020-12-01)

Synthesis of multivalent polymer–aptamer conjugates with enhanced inhibitory potency
-н: Martin JT, зэрэг
Хэвлэсэн: (2018-09-01)

Frequency divider with pulse shaper in PLL
-н: Khoo, Meng Heong.
Хэвлэсэн: (2011)

CMOS PLL synthesizers : analysis and design /
-н: 229661 Shu, Keliu, зэрэг
Хэвлэсэн: (2005)

Capturing resting T cells: the perils of PLL
-н: Santos, A, зэрэг
Хэвлэсэн: (2018)

Chaos Generation Using BJT's and PLL's
-н: Umesh Kumar
Хэвлэсэн: (2000-01-01)