Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo

Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo

<p style="text-align:justify;">Background: Gene delivery vectors based on poly(L‐lysine) and DNA (pLL/DNA complexes) have limited use for targeted systemic application in vivo since they bind cells and proteins non‐specifically. In this study we have attempted to form folate‐targeted...

書目詳細資料
Main Authors:	Ward, C, Pechar, M, Oupicky, D, Ulbrich, K, Seymour, L
格式:	Journal article
出版:	Wiley 2002

相似書籍

Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
由: Dash, P, et al.
出版: (2000)

Conjugation of Folate via Gelonin Carbohydrate Residues Retains Ribosomal-inactivating Properties of the Toxin and Permits Targeting to Folate Receptor Positive Cells
由: Atkinson, S, et al.
出版: (2001)

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
由: Fisher, K, et al.
出版: (2001)

Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.
由: Zhou, Q, et al.
出版: (2005)

Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA
由: Howard, K, et al.
出版: (2000)

Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
由: Oupicky, D, et al.
出版: (2002)

Surface modification of AAV5 permits polymer coating and inhibition of infection, with tropism restored by covalent linkage of new ligands
由: Carlisle, R, et al.
出版: (2004)

Application of Hydrophilic Polymers to the Preparation of Prolonged-Release Minitablets with Bromhexine Hydrochloride and Bisoprolol Fumarate
由: Agata Grzejdziak, et al.
出版: (2024-08-01)

Computational insights into multivalently binding polymers
由: Zumbro, Emiko.
出版: (2021)

Folate-Functionalization Enhances Cytotoxicity of Multivalent DNA Nanocages on Triple-Negative Breast Cancer Cells
由: Valeria Unida, et al.
出版: (2022-11-01)

Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.
由: Oupický, D, et al.
出版: (2001)

A Viral Platform for Chemical Modification and Multivalent Display
由: Peabody David S
出版: (2003-07-01)

Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations
由: Reschel, T, et al.
出版: (2002)

Subhourly rainfall in a convection-permitting model
由: Edmund P Meredith, et al.
出版: (2020-01-01)

Super-hydrophilic zwitterionic polymer surface modification facilitates liquid transportation of microfluidic sweat sensors
由: Fu, Fanfan, et al.
出版: (2022)

A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression
由: Fisher, KD, et al.
出版: (2000)

Hydrophilic polymers : performance with environmental acceptance /
由: Glass, J. E. (J. Edward), 1937-, et al.
出版: (1996)

Hydrophilic polymers in potting soil mix
由: T Furuta, et al.
出版: (1988-05-01)

Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds
由: Michaela Mühlberg, et al.
出版: (2015-05-01)

DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers
由: Oupický, D, et al.
出版: (2000)

Modification of surface hydrophilicity of dental materials by ozone
由: Ira Artilia
出版: (2019-07-01)

Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug Doxorubicin
由: Pechar, M, et al.
出版: (2000)

Macromodelling of a PLL system
由: Xue, Xiaoqing.
出版: (2009)

Optimization of PLL frequency synthesizer
由: G. A. Koshuk, et al.
出版: (2019-06-01)

T-PLL Presenting with an Indolent Course
由: Arsa Thammahong, et al.
出版: (2024-01-01)

X-Band PLL Synthesizer
由: P. Kutin, et al.
出版: (2006-04-01)

PLL design and investigation in CMOS
由: Jevgenij Charlamov
出版: (2010-02-01)

Influence of Binding Site Affinity Patterns on Binding of Multivalent Polymers
由: Zumbro, Emiko, et al.
出版: (2021)

Structure-conductivity studies in polymer electrolytes containing multivalent cations /
由: 263346 Madzlan Aziz
出版: (1996)

Influence of Binding Site Affinity Patterns on Binding of Multivalent Polymers
由: Emiko Zumbro, et al.
出版: (2020-05-01)

SPECTROSCOPIC STUDIES OF HETEROBIMETALLIC ADDUCTS OF TIN WITH Mn(ll), Co(ll), Cu(ll) AND Zn(ll)
由: Khan, Tahir Ali, et al.
出版: (1996-04-01)

INFLUENCE OF ACID MODIFICATION ON HYDROPHOBIC/HYDROPHILIC PROPERTIES OF CLINOPTILOLITE
由: Yu.V. Bondar
出版: (2023-10-01)

Pretreatment and Membrane Hydrophilic Modification to Reduce Membrane Fouling
由: Huaqiang Chu, et al.
出版: (2013-09-01)

Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation
由: Zumbro, Emiko, et al.
出版: (2022)

Review of Multivalent Metal Ion Transport in Inorganic and Solid Polymer Electrolytes
由: Lauren F. O’Donnell, et al.
出版: (2020-12-01)

Synthesis of multivalent polymer–aptamer conjugates with enhanced inhibitory potency
由: Martin JT, et al.
出版: (2018-09-01)

Frequency divider with pulse shaper in PLL
由: Khoo, Meng Heong.
出版: (2011)

CMOS PLL synthesizers : analysis and design /
由: 229661 Shu, Keliu, et al.
出版: (2005)

Capturing resting T cells: the perils of PLL
由: Santos, A, et al.
出版: (2018)

Chaos Generation Using BJT's and PLL's
由: Umesh Kumar
出版: (2000-01-01)