Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo

Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo

<p style="text-align:justify;">Background: Gene delivery vectors based on poly(L‐lysine) and DNA (pLL/DNA complexes) have limited use for targeted systemic application in vivo since they bind cells and proteins non‐specifically. In this study we have attempted to form folate‐targeted...

书目详细资料
Main Authors:	Ward, C, Pechar, M, Oupicky, D, Ulbrich, K, Seymour, L
格式:	Journal article
出版:	Wiley 2002

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