Peptide splicing by the proteasome.
The proteasome is the major protease responsible for the production of antigenic peptides recognized by CD8+ cytolytic T cells (CTL). These peptides, generally 8-to-10 amino acid-long, are presented at the cell surface by major histocompatibility complex (MHC) class I molecules. Although for years,...
| Váldodahkkit: | , , , , |
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| Materiálatiipa: | Journal article |
| Giella: | English |
| Almmustuhtton: |
American Society for Biochemistry and Molecular Biology
2017
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| _version_ | 1826272759166009344 |
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| author | Vigneron, N Ferrari, V Stroobant, V Abi Habib, J Van den Eynde, B |
| author_facet | Vigneron, N Ferrari, V Stroobant, V Abi Habib, J Van den Eynde, B |
| author_sort | Vigneron, N |
| collection | OXFORD |
| description | The proteasome is the major protease responsible for the production of antigenic peptides recognized by CD8+ cytolytic T cells (CTL). These peptides, generally 8-to-10 amino acid-long, are presented at the cell surface by major histocompatibility complex (MHC) class I molecules. Although for years, these peptides were believed to solely derive from linear fragments of proteins, this concept was challenged several years ago by the isolation of anti-tumor CTL that recognized spliced peptides, i.e. peptides composed of fragments originally distant in the parental protein. The splicing process was shown to take place in the proteasome through a transpeptidation reaction involving an acyl-enzyme intermediate. Here, we review the different steps that led to the discovery of spliced peptides as well as the recent advances in the field, which uncover the unexpected importance of spliced peptides in the composition of the MHC class I repertoire. |
| first_indexed | 2024-03-06T22:17:39Z |
| format | Journal article |
| id | oxford-uuid:53f4335d-54b5-4c12-8d05-cb2abf43e023 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:17:39Z |
| publishDate | 2017 |
| publisher | American Society for Biochemistry and Molecular Biology |
| record_format | dspace |
| spelling | oxford-uuid:53f4335d-54b5-4c12-8d05-cb2abf43e0232022-03-26T16:34:49ZPeptide splicing by the proteasome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:53f4335d-54b5-4c12-8d05-cb2abf43e023EnglishSymplectic Elements at OxfordAmerican Society for Biochemistry and Molecular Biology2017Vigneron, NFerrari, VStroobant, VAbi Habib, JVan den Eynde, BThe proteasome is the major protease responsible for the production of antigenic peptides recognized by CD8+ cytolytic T cells (CTL). These peptides, generally 8-to-10 amino acid-long, are presented at the cell surface by major histocompatibility complex (MHC) class I molecules. Although for years, these peptides were believed to solely derive from linear fragments of proteins, this concept was challenged several years ago by the isolation of anti-tumor CTL that recognized spliced peptides, i.e. peptides composed of fragments originally distant in the parental protein. The splicing process was shown to take place in the proteasome through a transpeptidation reaction involving an acyl-enzyme intermediate. Here, we review the different steps that led to the discovery of spliced peptides as well as the recent advances in the field, which uncover the unexpected importance of spliced peptides in the composition of the MHC class I repertoire. |
| spellingShingle | Vigneron, N Ferrari, V Stroobant, V Abi Habib, J Van den Eynde, B Peptide splicing by the proteasome. |
| title | Peptide splicing by the proteasome. |
| title_full | Peptide splicing by the proteasome. |
| title_fullStr | Peptide splicing by the proteasome. |
| title_full_unstemmed | Peptide splicing by the proteasome. |
| title_short | Peptide splicing by the proteasome. |
| title_sort | peptide splicing by the proteasome |
| work_keys_str_mv | AT vigneronn peptidesplicingbytheproteasome AT ferrariv peptidesplicingbytheproteasome AT stroobantv peptidesplicingbytheproteasome AT abihabibj peptidesplicingbytheproteasome AT vandeneyndeb peptidesplicingbytheproteasome |