Computational pharmacokinetics of solute penetration into human intervertebral discs-Effects of endplate permeability, solute molecular weight and disc size

A finite element model is developed to predict the penetration time-history of three different solutes into the human lumbar disc following intravenous injection. Antibiotics are routinely administered intravenously in spinal surgery to prevent disc infection. Successful prophylaxis requires antibio...

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Bibliografische gegevens
Hoofdauteurs: Motaghinasab, S, Shirazi-Adl, A, Urban, J, Parnianpour, M
Formaat: Journal article
Taal:English
Gepubliceerd in: 2012