Comparing mouse and human cingulate cortex organization using functional connectivity
The subdivisions of the extended cingulate cortex of the human brain are implicated in a number of high-level behaviors and affected by a range of neuropsychiatric disorders. Its anatomy, function, and response to therapeutics are often studied using non-human animals, including the mouse. However,...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer
2024
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| _version_ | 1817930986727407616 |
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| author | van Hout, ATB van Heukelum, S Rushworth, MFS Grandjean, J Mars, RB |
| author_facet | van Hout, ATB van Heukelum, S Rushworth, MFS Grandjean, J Mars, RB |
| author_sort | van Hout, ATB |
| collection | OXFORD |
| description | The subdivisions of the extended cingulate cortex of the human brain are implicated in a number of high-level behaviors and affected by a range of neuropsychiatric disorders. Its anatomy, function, and response to therapeutics are often studied using non-human animals, including the mouse. However, the similarity of human and mouse frontal cortex, including cingulate areas, is still not fully understood. Some accounts emphasize resemblances between mouse cingulate cortex and human cingulate cortex while others emphasize similarities with human granular prefrontal cortex. We use comparative neuroimaging to study the connectivity of the cingulate cortex in the mouse and human, allowing comparisons between mouse ‘gold standard’ tracer and imaging data, and, in addition, comparison between the mouse and the human using comparable imaging data. We find overall similarities in organization of the cingulate between species, including anterior and midcingulate areas and a retrosplenial area. However, human cingulate contains subareas with a more fine-grained organization than is apparent in the mouse and it has connections to prefrontal areas not present in the mouse. Results such as these help formally address between-species brain organization and aim to improve the translation from preclinical to human results. |
| first_indexed | 2024-12-09T03:14:51Z |
| format | Journal article |
| id | oxford-uuid:53fd84a8-34c5-40f7-adcc-fa7238ac2161 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:14:51Z |
| publishDate | 2024 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:53fd84a8-34c5-40f7-adcc-fa7238ac21612024-10-17T20:12:19ZComparing mouse and human cingulate cortex organization using functional connectivityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:53fd84a8-34c5-40f7-adcc-fa7238ac2161EnglishJisc Publications RouterSpringer2024van Hout, ATBvan Heukelum, SRushworth, MFSGrandjean, JMars, RBThe subdivisions of the extended cingulate cortex of the human brain are implicated in a number of high-level behaviors and affected by a range of neuropsychiatric disorders. Its anatomy, function, and response to therapeutics are often studied using non-human animals, including the mouse. However, the similarity of human and mouse frontal cortex, including cingulate areas, is still not fully understood. Some accounts emphasize resemblances between mouse cingulate cortex and human cingulate cortex while others emphasize similarities with human granular prefrontal cortex. We use comparative neuroimaging to study the connectivity of the cingulate cortex in the mouse and human, allowing comparisons between mouse ‘gold standard’ tracer and imaging data, and, in addition, comparison between the mouse and the human using comparable imaging data. We find overall similarities in organization of the cingulate between species, including anterior and midcingulate areas and a retrosplenial area. However, human cingulate contains subareas with a more fine-grained organization than is apparent in the mouse and it has connections to prefrontal areas not present in the mouse. Results such as these help formally address between-species brain organization and aim to improve the translation from preclinical to human results. |
| spellingShingle | van Hout, ATB van Heukelum, S Rushworth, MFS Grandjean, J Mars, RB Comparing mouse and human cingulate cortex organization using functional connectivity |
| title | Comparing mouse and human cingulate cortex organization using functional connectivity |
| title_full | Comparing mouse and human cingulate cortex organization using functional connectivity |
| title_fullStr | Comparing mouse and human cingulate cortex organization using functional connectivity |
| title_full_unstemmed | Comparing mouse and human cingulate cortex organization using functional connectivity |
| title_short | Comparing mouse and human cingulate cortex organization using functional connectivity |
| title_sort | comparing mouse and human cingulate cortex organization using functional connectivity |
| work_keys_str_mv | AT vanhoutatb comparingmouseandhumancingulatecortexorganizationusingfunctionalconnectivity AT vanheukelums comparingmouseandhumancingulatecortexorganizationusingfunctionalconnectivity AT rushworthmfs comparingmouseandhumancingulatecortexorganizationusingfunctionalconnectivity AT grandjeanj comparingmouseandhumancingulatecortexorganizationusingfunctionalconnectivity AT marsrb comparingmouseandhumancingulatecortexorganizationusingfunctionalconnectivity |