Antibody-induced transplantation tolerance: the role of dominant regulation.
A short-treatment with nondepleting antibodies, such as those targeting CD4 or CD154 (CD40 ligand), allows long-term graft survival without the need for continuous immunosuppression. This state of immune tolerance is maintained by regulatory CD4+ T cells present within both the lymphoid tissue and t...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797068999600635904 |
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| author | Graca, L Le Moine, A Cobbold, S Waldmann, H |
| author_facet | Graca, L Le Moine, A Cobbold, S Waldmann, H |
| author_sort | Graca, L |
| collection | OXFORD |
| description | A short-treatment with nondepleting antibodies, such as those targeting CD4 or CD154 (CD40 ligand), allows long-term graft survival without the need for continuous immunosuppression. This state of immune tolerance is maintained by regulatory CD4+ T cells present within both the lymphoid tissue and the tolerated graft. The nature of such regulatory T cells, their relationship to CD4+CD25+ T cells, and their mode of action have all been the subjects of much attention recently. Here, we review recent progress on understanding the nature, specificity, and mechanisms of action of T cells mediating dominant tolerance brought about by antibody therapy. |
| first_indexed | 2024-03-06T22:18:07Z |
| format | Journal article |
| id | oxford-uuid:541c2f42-daa7-42ae-a3e6-8bf417193e37 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:18:07Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:541c2f42-daa7-42ae-a3e6-8bf417193e372022-03-26T16:35:44ZAntibody-induced transplantation tolerance: the role of dominant regulation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:541c2f42-daa7-42ae-a3e6-8bf417193e37EnglishSymplectic Elements at Oxford2003Graca, LLe Moine, ACobbold, SWaldmann, HA short-treatment with nondepleting antibodies, such as those targeting CD4 or CD154 (CD40 ligand), allows long-term graft survival without the need for continuous immunosuppression. This state of immune tolerance is maintained by regulatory CD4+ T cells present within both the lymphoid tissue and the tolerated graft. The nature of such regulatory T cells, their relationship to CD4+CD25+ T cells, and their mode of action have all been the subjects of much attention recently. Here, we review recent progress on understanding the nature, specificity, and mechanisms of action of T cells mediating dominant tolerance brought about by antibody therapy. |
| spellingShingle | Graca, L Le Moine, A Cobbold, S Waldmann, H Antibody-induced transplantation tolerance: the role of dominant regulation. |
| title | Antibody-induced transplantation tolerance: the role of dominant regulation. |
| title_full | Antibody-induced transplantation tolerance: the role of dominant regulation. |
| title_fullStr | Antibody-induced transplantation tolerance: the role of dominant regulation. |
| title_full_unstemmed | Antibody-induced transplantation tolerance: the role of dominant regulation. |
| title_short | Antibody-induced transplantation tolerance: the role of dominant regulation. |
| title_sort | antibody induced transplantation tolerance the role of dominant regulation |
| work_keys_str_mv | AT gracal antibodyinducedtransplantationtolerancetheroleofdominantregulation AT lemoinea antibodyinducedtransplantationtolerancetheroleofdominantregulation AT cobbolds antibodyinducedtransplantationtolerancetheroleofdominantregulation AT waldmannh antibodyinducedtransplantationtolerancetheroleofdominantregulation |