Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis.
OBJECTIVES: To test the sensitivity to change of ultrasonographic endpoints in early phase clinical trials in subjects with active rheumatoid arthritis (RA). METHODS: A double-blind, placebo and comparator controlled, randomised, two-centre study investigated the effect on synovial thickness and va...
Glavni autori: | Seymour, M, Pétavy, F, Chiesa, F, Perry, H, Lukey, P, Binks, M, Donatien, P, Freidin, A, Eckersley, R, McClinton, C, Heath, K, Prodanovic, S, Radunovic, G, Pilipovic, N, Damjanov, N, Taylor, P |
---|---|
Format: | Journal article |
Jezik: | English |
Izdano: |
2012
|
Slični predmeti
-
Between-group differences in ultrasonographic measures of synovitis and kinetics of response to oral steroids in active RA
od: Larche, M, i dr.
Izdano: (2006) -
The effect of the potent and selective iNOS (NOS-2) inhibitor GW274150 in models of acute and establised inflammatory and neuropathic pain in the rat
od: Clayton, N, i dr.
Izdano: (2000) -
Quantitative power Doppler ultrasonography is a sensitive measure of metacarpophalangeal joint synovial vascularity in rheumatoid arthritis and declines significantly following a 2-week course of oral low-dose corticosteroids.
od: Larché, M, i dr.
Izdano: (2010) -
Colorectal distension-evoked iNOS, nitrotyrosine and C-FOS expression in the anaesthetised rat is inhibited by the selective iNOS inhibitor GW274150
od: Clayton, N, i dr.
Izdano: (2001) -
B-LYMPHOCYTE chemoattractant (BLC/CXCL13): A potential novel disease activity marker of rheumatoid arthritis
od: Pastor, I, i dr.
Izdano: (2007)