The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits
Human reproductive behavior until relatively recently has been explained exclusively via individual and social characteristics. This article applies results from a recent Genome-Wide Association Study that combined sixty-two data sources to isolate twelve genetic loci associated with reproductive be...
| Main Authors: | , , |
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| Formato: | Journal article |
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Russell Sage Foundation
2018
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| _version_ | 1826272791316398080 |
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| author | Mills, M Barban, N Tropf, F |
| author_facet | Mills, M Barban, N Tropf, F |
| author_sort | Mills, M |
| collection | OXFORD |
| description | Human reproductive behavior until relatively recently has been explained exclusively via individual and social characteristics. This article applies results from a recent Genome-Wide Association Study that combined sixty-two data sources to isolate twelve genetic loci associated with reproductive behavior. We create polygenic scores that allow us to include a summary variable of genetic factors into our statistical models. We use four datasets: the U.S. Health and Retirement Study, Dutch LifeLines, TwinsUK and the Swedish Twin register. First, we provide a brief overview of the dominant explanations of reproductive behavior. Second, we test the predictive power of polygenic scores. Third, we interrogate the robustness of our models using a series of sensitivity analyses to take into account possible confounders due to population stratification and selection. |
| first_indexed | 2024-03-06T22:18:09Z |
| format | Journal article |
| id | oxford-uuid:541f0728-cf72-49a7-a968-fb5087b95704 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:18:09Z |
| publishDate | 2018 |
| publisher | Russell Sage Foundation |
| record_format | dspace |
| spelling | oxford-uuid:541f0728-cf72-49a7-a968-fb5087b957042022-03-26T16:35:49ZThe sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traitsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:541f0728-cf72-49a7-a968-fb5087b95704Symplectic Elements at OxfordRussell Sage Foundation2018Mills, MBarban, NTropf, FHuman reproductive behavior until relatively recently has been explained exclusively via individual and social characteristics. This article applies results from a recent Genome-Wide Association Study that combined sixty-two data sources to isolate twelve genetic loci associated with reproductive behavior. We create polygenic scores that allow us to include a summary variable of genetic factors into our statistical models. We use four datasets: the U.S. Health and Retirement Study, Dutch LifeLines, TwinsUK and the Swedish Twin register. First, we provide a brief overview of the dominant explanations of reproductive behavior. Second, we test the predictive power of polygenic scores. Third, we interrogate the robustness of our models using a series of sensitivity analyses to take into account possible confounders due to population stratification and selection. |
| spellingShingle | Mills, M Barban, N Tropf, F The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits |
| title | The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits |
| title_full | The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits |
| title_fullStr | The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits |
| title_full_unstemmed | The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits |
| title_short | The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits |
| title_sort | sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits |
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