Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features
Diffusion magnetic resonance imaging (dMRI) is commonly used to assess the tissue and cellular substructure of the human brain. In the white matter, myelinated axons are the principal neural elements that shape dMRI through the restriction of water diffusion; however, in the gray matter the relative...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2022
|
| _version_ | 1797108783307030528 |
|---|---|
| author | Reveley, C Ye, FQ Mars, RB Matrov, D Chudasama, Y Leopold, DA |
| author_facet | Reveley, C Ye, FQ Mars, RB Matrov, D Chudasama, Y Leopold, DA |
| author_sort | Reveley, C |
| collection | OXFORD |
| description | Diffusion magnetic resonance imaging (dMRI) is commonly used to assess the tissue and cellular substructure of the human brain. In the white matter, myelinated axons are the principal neural elements that shape dMRI through the restriction of water diffusion; however, in the gray matter the relative contributions of myelinated axons and other tissue features to dMRI are poorly understood. Here we investigate the determinants of diffusion in the cerebral cortex. Specifically, we ask whether myelinated axons significantly shape dMRI fractional anisotropy (dMRI-FA), a measure commonly used to characterize tissue properties in humans. We compared ultra-high resolution ex vivo dMRI data from the brain of a marmoset monkey with both myelin- and Nissl-stained histological sections obtained from the same brain after scanning. We found that the dMRI-FA did not match the spatial distribution of myelin in the gray matter. Instead dMRI-FA was more closely related to the anisotropy of stained tissue features, most prominently those revealed by Nissl staining and to a lesser extent those revealed by myelin staining. Our results suggest that unmyelinated neurites such as large caliber apical dendrites are the primary features shaping dMRI measures in the cerebral cortex. |
| first_indexed | 2024-03-07T07:33:15Z |
| format | Journal article |
| id | oxford-uuid:542fb8e6-336c-4a4d-97ae-e99ad813f44f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:33:15Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:542fb8e6-336c-4a4d-97ae-e99ad813f44f2023-02-09T15:59:41ZDiffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue featuresJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:542fb8e6-336c-4a4d-97ae-e99ad813f44fEnglishSymplectic ElementsSpringer Nature2022Reveley, CYe, FQMars, RBMatrov, DChudasama, YLeopold, DADiffusion magnetic resonance imaging (dMRI) is commonly used to assess the tissue and cellular substructure of the human brain. In the white matter, myelinated axons are the principal neural elements that shape dMRI through the restriction of water diffusion; however, in the gray matter the relative contributions of myelinated axons and other tissue features to dMRI are poorly understood. Here we investigate the determinants of diffusion in the cerebral cortex. Specifically, we ask whether myelinated axons significantly shape dMRI fractional anisotropy (dMRI-FA), a measure commonly used to characterize tissue properties in humans. We compared ultra-high resolution ex vivo dMRI data from the brain of a marmoset monkey with both myelin- and Nissl-stained histological sections obtained from the same brain after scanning. We found that the dMRI-FA did not match the spatial distribution of myelin in the gray matter. Instead dMRI-FA was more closely related to the anisotropy of stained tissue features, most prominently those revealed by Nissl staining and to a lesser extent those revealed by myelin staining. Our results suggest that unmyelinated neurites such as large caliber apical dendrites are the primary features shaping dMRI measures in the cerebral cortex. |
| spellingShingle | Reveley, C Ye, FQ Mars, RB Matrov, D Chudasama, Y Leopold, DA Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features |
| title | Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features |
| title_full | Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features |
| title_fullStr | Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features |
| title_full_unstemmed | Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features |
| title_short | Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features |
| title_sort | diffusion mri anisotropy in the cerebral cortex is determined by unmyelinated tissue features |
| work_keys_str_mv | AT reveleyc diffusionmrianisotropyinthecerebralcortexisdeterminedbyunmyelinatedtissuefeatures AT yefq diffusionmrianisotropyinthecerebralcortexisdeterminedbyunmyelinatedtissuefeatures AT marsrb diffusionmrianisotropyinthecerebralcortexisdeterminedbyunmyelinatedtissuefeatures AT matrovd diffusionmrianisotropyinthecerebralcortexisdeterminedbyunmyelinatedtissuefeatures AT chudasamay diffusionmrianisotropyinthecerebralcortexisdeterminedbyunmyelinatedtissuefeatures AT leopoldda diffusionmrianisotropyinthecerebralcortexisdeterminedbyunmyelinatedtissuefeatures |