Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.

Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.

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X chromosome inactivation involves multiple levels of chromatin modification, established progressively and in a stepwise manner during early development. The chromosomal protein Smchd1 was recently shown to play an important role in DNA methylation of CpG islands (CGIs), a late step in the X inacti...

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Bibliographic Details
Main Authors: Gendrel, A, Apedaile, A, Coker, H, Termanis, A, Zvetkova, I, Godwin, J, Tang, Y, Huntley, D, Montana, G, Taylor, S, Giannoulatou, E, Heard, E, Stancheva, I, Brockdorff, N
Format: Journal article
Language:English
Published: 2012

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