Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study
<p><strong>Background:</strong> The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID–19.</p> <p><strong>Methods:</s...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2021
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| _version_ | 1797069035093884928 |
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| author | Roozeman, J-P Mazzinari, G Serpa Neto, A Hollmann, MW Paulus, F Schultz, M Pisani, L |
| author2 | PRoVENT-COVID Collaborative Group |
| author_facet | PRoVENT-COVID Collaborative Group Roozeman, J-P Mazzinari, G Serpa Neto, A Hollmann, MW Paulus, F Schultz, M Pisani, L |
| author_sort | Roozeman, J-P |
| collection | OXFORD |
| description | <p><strong>Background:</strong> The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID–19.</p>
<p><strong>Methods:</strong> This was a post-hoc analysis of a national multicenter cohort study in invasively ventilated patients with ARDS due to COVID–19. The primary endpoint was 28–day mortality.</p>
<p><strong>Results:</strong> In 869 invasively ventilated patients, 28–day mortality was 30.1%. The SpO2/FiO2 on day 1 had no prognostic value. The SpO2/FiO2 on day 2 and day 3 had prognostic capacity for death, with the best cut-offs being 179 and 199, respectively. Both SpO2/FiO2 on day 2 (OR, 0.66 [95%–CI 0.46–0.96]) and on day 3 (OR, 0.70 [95%–CI 0.51–0.96]) were associated with 28–day mortality in a model corrected for age, pH, lactate levels and kidney dysfunction (AUROC 0.78 [0.76–0.79]). The measured PaO2/FiO2 and the PaO2/FiO2 calculated from SpO2/FiO2 were strongly correlated (Spearman's r = 0.79).</p>
<p><strong>Conclusions:</strong> In this cohort of patients with ARDS due to COVID–19, the SpO2/FiO2 on day 2 and day 3 are independently associated with and have prognostic capacity for 28–day mortality. The SpO2/FiO2 is a useful metric for risk stratification in invasively ventilated COVID–19 patients.</p> |
| first_indexed | 2024-03-06T22:18:39Z |
| format | Journal article |
| id | oxford-uuid:544541fa-9226-47ab-a8cc-f405e5a111d3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:18:39Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:544541fa-9226-47ab-a8cc-f405e5a111d32022-03-26T16:36:51ZPrognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:544541fa-9226-47ab-a8cc-f405e5a111d3EnglishSymplectic ElementsElsevier2021Roozeman, J-PMazzinari, GSerpa Neto, AHollmann, MWPaulus, FSchultz, MPisani, LPRoVENT-COVID Collaborative Group<p><strong>Background:</strong> The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID–19.</p> <p><strong>Methods:</strong> This was a post-hoc analysis of a national multicenter cohort study in invasively ventilated patients with ARDS due to COVID–19. The primary endpoint was 28–day mortality.</p> <p><strong>Results:</strong> In 869 invasively ventilated patients, 28–day mortality was 30.1%. The SpO2/FiO2 on day 1 had no prognostic value. The SpO2/FiO2 on day 2 and day 3 had prognostic capacity for death, with the best cut-offs being 179 and 199, respectively. Both SpO2/FiO2 on day 2 (OR, 0.66 [95%–CI 0.46–0.96]) and on day 3 (OR, 0.70 [95%–CI 0.51–0.96]) were associated with 28–day mortality in a model corrected for age, pH, lactate levels and kidney dysfunction (AUROC 0.78 [0.76–0.79]). The measured PaO2/FiO2 and the PaO2/FiO2 calculated from SpO2/FiO2 were strongly correlated (Spearman's r = 0.79).</p> <p><strong>Conclusions:</strong> In this cohort of patients with ARDS due to COVID–19, the SpO2/FiO2 on day 2 and day 3 are independently associated with and have prognostic capacity for 28–day mortality. The SpO2/FiO2 is a useful metric for risk stratification in invasively ventilated COVID–19 patients.</p> |
| spellingShingle | Roozeman, J-P Mazzinari, G Serpa Neto, A Hollmann, MW Paulus, F Schultz, M Pisani, L Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study |
| title | Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study |
| title_full | Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study |
| title_fullStr | Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study |
| title_full_unstemmed | Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study |
| title_short | Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study |
| title_sort | prognostication using spo2 fio2 in invasively ventilated icu patients with ards due to covid 19 insights from the provent covid study |
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