Review: the role of vitamin D in nervous system health and disease.
Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurolo...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2013
|
| _version_ | 1826272845016072192 |
|---|---|
| author | DeLuca, G Kimball, S Kolasinski, J Ramagopalan, S Ebers, G |
| author_facet | DeLuca, G Kimball, S Kolasinski, J Ramagopalan, S Ebers, G |
| author_sort | DeLuca, G |
| collection | OXFORD |
| description | Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurological diseases. The conflation of in vitro, ex vivo, and animal model data provide compelling evidence that vitamin D has a crucial role in proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. Vitamin D exerts its biological function not only by influencing cellular processes directly, but also by influencing gene expression through vitamin D response elements. This review highlights the epidemiological, neuropathological, experimental and molecular genetic evidence implicating vitamin D as a candidate in influencing susceptibility to a number of psychiatric and neurological diseases. The strength of evidence varies for schizophrenia, autism, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, and is especially strong for multiple sclerosis. |
| first_indexed | 2024-03-06T22:19:01Z |
| format | Journal article |
| id | oxford-uuid:5463f149-3f03-4614-adee-cf339334f28e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:19:01Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:5463f149-3f03-4614-adee-cf339334f28e2022-03-26T16:37:32ZReview: the role of vitamin D in nervous system health and disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5463f149-3f03-4614-adee-cf339334f28eEnglishSymplectic Elements at Oxford2013DeLuca, GKimball, SKolasinski, JRamagopalan, SEbers, GVitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurological diseases. The conflation of in vitro, ex vivo, and animal model data provide compelling evidence that vitamin D has a crucial role in proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. Vitamin D exerts its biological function not only by influencing cellular processes directly, but also by influencing gene expression through vitamin D response elements. This review highlights the epidemiological, neuropathological, experimental and molecular genetic evidence implicating vitamin D as a candidate in influencing susceptibility to a number of psychiatric and neurological diseases. The strength of evidence varies for schizophrenia, autism, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, and is especially strong for multiple sclerosis. |
| spellingShingle | DeLuca, G Kimball, S Kolasinski, J Ramagopalan, S Ebers, G Review: the role of vitamin D in nervous system health and disease. |
| title | Review: the role of vitamin D in nervous system health and disease. |
| title_full | Review: the role of vitamin D in nervous system health and disease. |
| title_fullStr | Review: the role of vitamin D in nervous system health and disease. |
| title_full_unstemmed | Review: the role of vitamin D in nervous system health and disease. |
| title_short | Review: the role of vitamin D in nervous system health and disease. |
| title_sort | review the role of vitamin d in nervous system health and disease |
| work_keys_str_mv | AT delucag reviewtheroleofvitamindinnervoussystemhealthanddisease AT kimballs reviewtheroleofvitamindinnervoussystemhealthanddisease AT kolasinskij reviewtheroleofvitamindinnervoussystemhealthanddisease AT ramagopalans reviewtheroleofvitamindinnervoussystemhealthanddisease AT ebersg reviewtheroleofvitamindinnervoussystemhealthanddisease |