Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cell...

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Bibliographic Details
Main Authors:	Markkanen, E, Fischer, R, Ledentcova, M, Kessler, B, Dianov, G
Format:	Journal article
Language:	English
Published:	Oxford University Press 2015

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