Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cell...

Descripció completa

Dades bibliogràfiques
Autors principals:	Markkanen, E, Fischer, R, Ledentcova, M, Kessler, B, Dianov, G
Format:	Journal article
Idioma:	English
Publicat:	Oxford University Press 2015

Ítems similars

p53 coordinates base excision repair to prevent genomic instability
per: Poletto, M, et al.
Publicat: (2016)

Base excision repair targets for cancer therapy.
per: Dianov, G
Publicat: (2011)

Monitoring base excision repair by in vitro assays.
per: Dianov, G
Publicat: (2003)

Targeting base excision repair to improve cancer therapies.
per: Sharma, R, et al.
Publicat: (2007)

Mammalian base excision repair: the forgotten archangel.
per: Dianov, G, et al.
Publicat: (2013)

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells
per: Poletto, M, et al.
Publicat: (2017)

Base excision repair fidelity in normal and cancer cells.
per: Chan, K, et al.
Publicat: (2006)

DNA repair fidelity of base excision repair pathways in human cell extracts.
per: Zhang, Q, et al.
Publicat: (2005)

Co-ordination of base excision repair and genome stability.
per: Parsons, J, et al.
Publicat: (2013)

The emerging role of Mule and ARF in the regulation of base excision repair.
per: Khoronenkova, S, et al.
Publicat: (2011)

The emerging role of Mule and ARF in the regulation of base excision repair
per: Khoronenkova, S, et al.
Publicat: (2011)

In vitro base excision repair using mammalian cell extracts.
per: Parsons, J, et al.
Publicat: (2012)

Orchestration of base excision repair by controlling the rates of enzymatic activities.
per: Allinson, S, et al.
Publicat: (2004)

DNA base excision repair: the Achilles' heel of tumour cells and their microenvironment?
per: Poletto, M, et al.
Publicat: (2017)

Exchangeability of mammalian DNA ligases between base excision repair pathways.
per: Sleeth, K, et al.
Publicat: (2004)

Monitoring base excision repair proteins on damaged DNA using human cell extracts.
per: Parsons, J, et al.
Publicat: (2004)

Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.
per: Yang, J, et al.
Publicat: (2010)

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
per: Parsons, J, et al.
Publicat: (2009)

Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice
per: Flavia S. Mueller, et al.
Publicat: (2022-07-01)

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
per: Parsons, J, et al.
Publicat: (2011)

Mismatch Repair Deficiency and Microsatellite Instability
per: Sandra Schöniger, et al.
Publicat: (2022-08-01)

Chromosomal Instability as Enabling Feature and Central Hallmark of Breast Cancer
per: Castellanos G, et al.
Publicat: (2023-03-01)

Chronic muscle pain and spasm hallmarks of spinal instability
per: Atul Goel
Publicat: (2024-09-01)

DNA repair, genetic instability, and cancer /
per: Davis, J. R. (Joseph R.)
Publicat: (2007)

DNA repair as a shared hallmark in cancer and ageing
per: Thomas L. Clarke, et al.
Publicat: (2022-09-01)

XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.
per: Dianova, I, et al.
Publicat: (2004)

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
per: Parsons, J, et al.
Publicat: (2008)

DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
per: Parsons, J, et al.
Publicat: (2005)

Isolation of a small molecule inhibitor of DNA base excision repair.
per: Madhusudan, S, et al.
Publicat: (2005)

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms
per: Diletta Edifizi, et al.
Publicat: (2015-08-01)

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
per: Chan, K, et al.
Publicat: (2007)

Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
per: Arjan F Theil, et al.
Publicat: (2013-04-01)

Instability of CTG repeats is governed by the position of a DNA base lesion through base excision repair.
per: Yanhao Lai, et al.
Publicat: (2013-01-01)

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency
per: Thomas Chabot, et al.
Publicat: (2022-11-01)

Uncovering the role of mismatch repair deficiency and microsatellite instability in urothelial carcinoma
per: Filippo Pietrantonio, et al.
Publicat: (2024-07-01)

Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
per: Maja L. Nádorvári, et al.
Publicat: (2024-04-01)

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
per: Sakuya Inanaga, et al.
Publicat: (2022-09-01)

Genetic Variations in Nucleotide Excision Repair Pathway Genes and Risk of Allergic Rhinitis
per: Wenlong Liu, et al.
Publicat: (2022-01-01)

Multi‐organ transcriptomic atlas reveals hallmarks of labour
per: Duan Ni, et al.
Publicat: (2025-02-01)

Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients
per: Chen, X, et al.
Publicat: (2018)