Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cell...

Podrobná bibliografie
Hlavní autoři:	Markkanen, E, Fischer, R, Ledentcova, M, Kessler, B, Dianov, G
Médium:	Journal article
Jazyk:	English
Vydáno:	Oxford University Press 2015

Podobné jednotky

p53 coordinates base excision repair to prevent genomic instability
Autor: Poletto, M, a další
Vydáno: (2016)

Base excision repair targets for cancer therapy.
Autor: Dianov, G
Vydáno: (2011)

Monitoring base excision repair by in vitro assays.
Autor: Dianov, G
Vydáno: (2003)

Targeting base excision repair to improve cancer therapies.
Autor: Sharma, R, a další
Vydáno: (2007)

Mammalian base excision repair: the forgotten archangel.
Autor: Dianov, G, a další
Vydáno: (2013)

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells
Autor: Poletto, M, a další
Vydáno: (2017)

Base excision repair fidelity in normal and cancer cells.
Autor: Chan, K, a další
Vydáno: (2006)

DNA repair fidelity of base excision repair pathways in human cell extracts.
Autor: Zhang, Q, a další
Vydáno: (2005)

Co-ordination of base excision repair and genome stability.
Autor: Parsons, J, a další
Vydáno: (2013)

The emerging role of Mule and ARF in the regulation of base excision repair.
Autor: Khoronenkova, S, a další
Vydáno: (2011)

The emerging role of Mule and ARF in the regulation of base excision repair
Autor: Khoronenkova, S, a další
Vydáno: (2011)

In vitro base excision repair using mammalian cell extracts.
Autor: Parsons, J, a další
Vydáno: (2012)

Orchestration of base excision repair by controlling the rates of enzymatic activities.
Autor: Allinson, S, a další
Vydáno: (2004)

DNA base excision repair: the Achilles' heel of tumour cells and their microenvironment?
Autor: Poletto, M, a další
Vydáno: (2017)

Exchangeability of mammalian DNA ligases between base excision repair pathways.
Autor: Sleeth, K, a další
Vydáno: (2004)

Monitoring base excision repair proteins on damaged DNA using human cell extracts.
Autor: Parsons, J, a další
Vydáno: (2004)

Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.
Autor: Yang, J, a další
Vydáno: (2010)

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
Autor: Parsons, J, a další
Vydáno: (2009)

Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice
Autor: Flavia S. Mueller, a další
Vydáno: (2022-07-01)

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
Autor: Parsons, J, a další
Vydáno: (2011)

Mismatch Repair Deficiency and Microsatellite Instability
Autor: Sandra Schöniger, a další
Vydáno: (2022-08-01)

Chromosomal Instability as Enabling Feature and Central Hallmark of Breast Cancer
Autor: Castellanos G, a další
Vydáno: (2023-03-01)

Chronic muscle pain and spasm hallmarks of spinal instability
Autor: Atul Goel
Vydáno: (2024-09-01)

DNA repair, genetic instability, and cancer /
Autor: Davis, J. R. (Joseph R.)
Vydáno: (2007)

DNA repair as a shared hallmark in cancer and ageing
Autor: Thomas L. Clarke, a další
Vydáno: (2022-09-01)

XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.
Autor: Dianova, I, a další
Vydáno: (2004)

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
Autor: Parsons, J, a další
Vydáno: (2008)

DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
Autor: Parsons, J, a další
Vydáno: (2005)

Isolation of a small molecule inhibitor of DNA base excision repair.
Autor: Madhusudan, S, a další
Vydáno: (2005)

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms
Autor: Diletta Edifizi, a další
Vydáno: (2015-08-01)

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
Autor: Chan, K, a další
Vydáno: (2007)

Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
Autor: Arjan F Theil, a další
Vydáno: (2013-04-01)

Instability of CTG repeats is governed by the position of a DNA base lesion through base excision repair.
Autor: Yanhao Lai, a další
Vydáno: (2013-01-01)

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency
Autor: Thomas Chabot, a další
Vydáno: (2022-11-01)

Uncovering the role of mismatch repair deficiency and microsatellite instability in urothelial carcinoma
Autor: Filippo Pietrantonio, a další
Vydáno: (2024-07-01)

Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
Autor: Maja L. Nádorvári, a další
Vydáno: (2024-04-01)

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
Autor: Sakuya Inanaga, a další
Vydáno: (2022-09-01)

Genetic Variations in Nucleotide Excision Repair Pathway Genes and Risk of Allergic Rhinitis
Autor: Wenlong Liu, a další
Vydáno: (2022-01-01)

Multi‐organ transcriptomic atlas reveals hallmarks of labour
Autor: Duan Ni, a další
Vydáno: (2025-02-01)

Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients
Autor: Chen, X, a další
Vydáno: (2018)