IFITM3 and susceptibility to respiratory viral infections in the community.
Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influen...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
University of Chicago Press
2014
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| _version_ | 1826272864764952576 |
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| author | Mills, T Rautanen, A Elliott, K Parks, T Naranbhai, V Ieven, M Butler, C Little, P Verheij, T Garrard, C Hinds, C Goossens, H Chapman, S Hill, A |
| author_facet | Mills, T Rautanen, A Elliott, K Parks, T Naranbhai, V Ieven, M Butler, C Little, P Verheij, T Garrard, C Hinds, C Goossens, H Chapman, S Hill, A |
| author_sort | Mills, T |
| collection | OXFORD |
| description | Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection. |
| first_indexed | 2024-03-06T22:19:19Z |
| format | Journal article |
| id | oxford-uuid:547c1f8e-cbe0-4569-8082-a37a880865c4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:19:19Z |
| publishDate | 2014 |
| publisher | University of Chicago Press |
| record_format | dspace |
| spelling | oxford-uuid:547c1f8e-cbe0-4569-8082-a37a880865c42022-03-26T16:38:11ZIFITM3 and susceptibility to respiratory viral infections in the community.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:547c1f8e-cbe0-4569-8082-a37a880865c4EnglishSymplectic Elements at OxfordUniversity of Chicago Press2014Mills, TRautanen, AElliott, KParks, TNaranbhai, VIeven, MButler, CLittle, PVerheij, TGarrard, CHinds, CGoossens, HChapman, SHill, AInterferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection. |
| spellingShingle | Mills, T Rautanen, A Elliott, K Parks, T Naranbhai, V Ieven, M Butler, C Little, P Verheij, T Garrard, C Hinds, C Goossens, H Chapman, S Hill, A IFITM3 and susceptibility to respiratory viral infections in the community. |
| title | IFITM3 and susceptibility to respiratory viral infections in the community. |
| title_full | IFITM3 and susceptibility to respiratory viral infections in the community. |
| title_fullStr | IFITM3 and susceptibility to respiratory viral infections in the community. |
| title_full_unstemmed | IFITM3 and susceptibility to respiratory viral infections in the community. |
| title_short | IFITM3 and susceptibility to respiratory viral infections in the community. |
| title_sort | ifitm3 and susceptibility to respiratory viral infections in the community |
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