Investigating the complex arrhythmic phenotype caused by the gain-of-function mutation KCNQ1-G229D

Investigating the complex arrhythmic phenotype caused by the gain-of-function mutation KCNQ1-G229D

The congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder that can cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (IKs), which is essential for cardiac repolarization. Paradoxically, g...

Bibliografski detalji
Glavni autori:	Zhou, X, Bueno Orovio, A, Schilling, R, Kirkby, C, Denning, C, Rajamohan, D, Burrage, K, Tinker, A, Rodriguez, B, Harmer, S
Format:	Journal article
Izdano:	Frontiers Media 2019

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