Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma

Human type-2 CD8+ T-cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia - a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Hilvering, B, Hinks, T, Stoeger, L, Marchi, E, Salimi, M, Shrimanker, R, Liu, W, Chen, W, Luo, J, Go, S, Powell, T, Cane, J, Thulborn, S, Kurioka, A, Leng, T, Matthews, J, Connolly, C, Borg, C, Bafadhel, M, Willberg, C, Ramasamy, A, Djukanovic, R, Ogg, G, Pavord, I, Klenerman, P, Xue, L
Формат:	Journal article
Хэвлэсэн:	Nature Publishing Group 2018

Ижил төстэй зүйлс

Type-2 CD8+ T lymphocytes responsive to PGD2/LTE4 in severe eosinophilic asthma
-н: Hinks, T, зэрэг
Хэвлэсэн: (2018)

Sputum Il-17a levels correlate with biomarkers of non-eosinophilic inflammation in patients with asthma
-н: Hynes, G, зэрэг
Хэвлэсэн: (2017)

Interaction of type 2 cytotoxic T lymphocytes and mast cell lipid mediators contributes to pathogenesis of eosinophilic asthma
-н: Xue, L, зэрэг
Хэвлэсэн: (2017)

The peripheral blood eosinophil count as a biomarker of eosinophilic airway inflammation in patients with asthma and COPD. Experience from a single centre
-н: Shrimanker, R, зэрэг
Хэвлэсэн: (2017)

Identification of pulmonary treatable traits in a real-life setting
-н: Simpson, J, зэрэг
Хэвлэсэн: (2018)

Clinical outcomes with mepolizumab therapy in routine practice in the oxford cohort
-н: Gittins, A, зэрэг
Хэвлэсэн: (2018)

Does a composite score combining peripheral blood eosinophils (PBE) and exhaled nitric oxide (FeNO) accurately predict a sputum eosinophilia?
-н: Connolly, CM, зэрэг
Хэвлэсэн: (2017)

The effect of oral corticosteroids on circulating type-2 cytokine producing cells in patients with severe eosinophilic asthma
-н: Hynes, G, зэрэг
Хэвлэсэн: (2018)

Evaluating the sensitivity and specificity of Neatstik® technology compared to an activity-based immunoassay in sputum samples
-н: Thulborn, S, зэрэг
Хэвлэсэн: (2018)

Identifying bacterial airways infection in stable severe asthma using Oxford nanopore sequencing technologies
-н: Jabeen, MF, зэрэг
Хэвлэсэн: (2022)

Blood eosinophil depletion with mepolizumab, benralizumab and prednisolone in eosinophilic asthma
-н: Moran, AM, зэрэг
Хэвлэсэн: (2020)

IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma
-н: Luo, J, зэрэг
Хэвлэсэн: (2024)

Can NPT be used to distinguish eosinophilic inflammatory phenotypes in COPD?
-н: Hambleton, K, зэрэг
Хэвлэсэн: (2016)

Case series of long-term macrolide therapy effect on eosinophil count in COPD
-н: Asciak, R, зэрэг
Хэвлэсэн: (2017)

Depletion rate of blood eosinophils with mepolizumab, benralizumab and oral prednisolone in patients with severe asthma
-н: Moran, A, зэрэг
Хэвлэсэн: (2020)

Emerging biologics in severe asthma
-н: Pavord, I, зэрэг
Хэвлэсэн: (2016)

Longitudinal changes in sputum and blood inflammatory mediators during FeNO suppression testing
-н: Couillard, S, зэрэг
Хэвлэсэн: (2022)

Peripheral blood eosinophil drop-to-drop variation in patients with COPD using near patient testing: a small validation study
-н: Jeffers, H, зэрэг
Хэвлэсэн: (2017)

Cysteinyl leukotriene E4 activates human ILC2s and enhances the effect of prostaglandin D2 and epithelial cytokines
-н: Salimi, M, зэрэг
Хэвлэсэн: (2017)

Seasonality of eosinophilic and non-eosinophilic exacerbations of COPD
-н: Barker, R, зэрэг
Хэвлэсэн: (2017)

S14 Eosinophil activation status and CD62L expression in airways disease
-н: Cane, J, зэрэг
Хэвлэсэн: (2018)

Eosinophil migration is enhanced towards IL-5 and eotaxin in COPD
-н: Lababidi, R, зэрэг
Хэвлэсэн: (2017)

Evidence for the efficacy and safety of anti- interleukin-5 treatment in the management of refractory eosinophilic asthma
-н: Xue, L, зэрэг
Хэвлэсэн: (2015)

The effect of corticosteroids on internalisation of non-typeable Haemophilus influenzae into epithelial cells
-н: Cane, J, зэрэг
Хэвлэсэн: (2017)

Glucocorticoid receptor α and β expression in bronchial epithelial cells infected with NTHi
-н: Parker, L, зэрэг
Хэвлэсэн: (2017)

Free-living Haemophilus Influenzae is associated with increased pulmonary inflammation
-н: Thulborn, S, зэрэг
Хэвлэсэн: (2015)

Mepolizumab and the response to oral prednisolone in patients with severe eosinophilic asthma
-н: Shrimanker, R, зэрэг
Хэвлэсэн: (2017)

Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma
-н: Bart Hilvering, зэрэг
Хэвлэсэн: (2015-08-01)

Shall we focus on the eosinophil to guide treatment with systemic corticosteroids during acute exacerbations of COPD?: PRO
-н: Camp, J, зэрэг
Хэвлэсэн: (2018)

Antimicrobial peptides in inflammatory phenotypes of COPD
-н: Cane, J, зэрэг
Хэвлэсэн: (2017)

Eosinophils in COPD: just another biomarker?
-н: Bafadhel, M, зэрэг
Хэвлэсэн: (2017)

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes
-н: Kurioka, A, зэрэг
Хэвлэсэн: (2018)

Identifying Bacterial Airways Infection in Stable Severe Asthma Using Oxford Nanopore Sequencing Technologies
-н: Maisha F. Jabeen, зэрэг
Хэвлэсэн: (2022-04-01)

Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1
-н: Cane J, зэрэг
Хэвлэсэн: (2021-05-01)

Diagnosing eosinophilic asthma using a multivariate prediction model based on blood granulocyte responsiveness.
-н: Hilvering, B, зэрэг
Хэвлэсэн: (2016)

Mechanisms of FeNO non-suppression in severe asthma: analysis of sputum type 2 cytokines and chemokines
-н: Couillard, S, зэрэг
Хэвлэсэн: (2020)

Comparison of the peripheral blood eosinophil count using near-patient testing and standard automated laboratory measurement in healthy, asthmatic and COPD subjects
-н: Hambleton, K, зэрэг
Хэвлэсэн: (2017)

Inhibition of asthma-related immunological responses in mast cells and Th2 cell lines by cultured epithelial cell lines
-н: Powell, T, зэрэг
Хэвлэсэн: (2016)

Characterisation of exacerbations of severe eosinophilic asthma (SEA) on mepolizumab compared to placebo
-н: Shrimanker, R, зэрэг
Хэвлэсэн: (2017)

Fractional exhaled nitric oxide and the peripheral blood eosinophil count as biomarkers of the response to mepolizumab in patients with severe eosinophilic asthma
-н: Shrimanker, R, зэрэг
Хэвлэсэн: (2018)