Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma

Human type-2 CD8+ T-cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia - a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies...

Celý popis

Podrobná bibliografie
Hlavní autoři: Hilvering, B, Hinks, T, Stoeger, L, Marchi, E, Salimi, M, Shrimanker, R, Liu, W, Chen, W, Luo, J, Go, S, Powell, T, Cane, J, Thulborn, S, Kurioka, A, Leng, T, Matthews, J, Connolly, C, Borg, C, Bafadhel, M, Willberg, C, Ramasamy, A, Djukanovic, R, Ogg, G, Pavord, I, Klenerman, P, Xue, L
Médium: Journal article
Vydáno: Nature Publishing Group 2018

Podobné jednotky

Podobné jednotky