The emerging neurobiology of bipolar disorder
Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the dis...
| Päätekijät: | , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
American Psychiatric Publishing
2019
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| _version_ | 1826272935488258048 |
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| author | Harrison, PJ Geddes, JR Tunbridge, EM |
| author_facet | Harrison, PJ Geddes, JR Tunbridge, EM |
| author_sort | Harrison, PJ |
| collection | OXFORD |
| description | Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. BD illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches.
(Reprinted with permission from Trends in Neurosciences, January 2018, Vol. 41, No. 1 ) |
| first_indexed | 2024-03-06T22:20:25Z |
| format | Journal article |
| id | oxford-uuid:54dbb92d-f560-4eda-82f7-a8920b05ca10 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:20:25Z |
| publishDate | 2019 |
| publisher | American Psychiatric Publishing |
| record_format | dspace |
| spelling | oxford-uuid:54dbb92d-f560-4eda-82f7-a8920b05ca102022-03-26T16:40:23ZThe emerging neurobiology of bipolar disorderJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:54dbb92d-f560-4eda-82f7-a8920b05ca10EnglishSymplectic ElementsAmerican Psychiatric Publishing2019Harrison, PJGeddes, JRTunbridge, EMBipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. BD illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches. (Reprinted with permission from Trends in Neurosciences, January 2018, Vol. 41, No. 1 ) |
| spellingShingle | Harrison, PJ Geddes, JR Tunbridge, EM The emerging neurobiology of bipolar disorder |
| title | The emerging neurobiology of bipolar disorder |
| title_full | The emerging neurobiology of bipolar disorder |
| title_fullStr | The emerging neurobiology of bipolar disorder |
| title_full_unstemmed | The emerging neurobiology of bipolar disorder |
| title_short | The emerging neurobiology of bipolar disorder |
| title_sort | emerging neurobiology of bipolar disorder |
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